Insulin Degludec

75 interactions 3 explained in plain English

Also sold as: Tresiba

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Orlistat Miglitol Gemifloxacin Metoclopramide Nasal Spray Metoclopramide Injection Moxifloxacin Injection

36 Major 39 Moderate

All (75) Major (36) Moderate (39)

Moderate

Insulin Degludec Acebutolol Sectral® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Insulin Degludec Benazepril Lotensin An increased risk of hypoglycemia Details Insulin Degludec Azilsartan Edarbi Increased risk of hypoglycemia Details Insulin Degludec Betaxolol Betoptic S Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Insulin Degludec Betaxolol Ophthalmic Betoptic® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Insulin Degludec Bisoprolol Zebeta® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Insulin Degludec Candesartan Atacand Increased risk of hypoglycemia Details Insulin Degludec Captopril Capoten® An increased risk of hypoglycemia Details Insulin Degludec Clonidine Transdermal Patch Catapres An increased risk of hypoglycemia or hyperglycemia Details Insulin Degludec Disopyramide Norpace Increased risk of hypoglycemia Details Insulin Degludec Dulaglutide Injection Trulicity An increased risk of hypoglycemia Details Insulin Degludec Enalapril Epaned An increased risk of hypoglycemia Details Insulin Degludec Eprosartan Teveten® Increased risk of hypoglycemia Details Insulin Degludec Esmolol Brevibloc Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Insulin Degludec Fosinopril Monopril® An increased risk of hypoglycemia Details Insulin Degludec Gemfibrozil Lopid An increased risk of hypoglycemia Details Insulin Degludec Glucagon Injection Baqsimi Decreased blood glucose-lowering effects; interference with glucagon action Details Insulin Degludec Glucagon Injection / Solution Baqsimi Decreased blood glucose-lowering effects; interference with glucagon action Details Insulin Degludec Glucagon Nasal Powder Baqsimi Decreased blood glucose-lowering effects; interference with glucagon action Details Insulin Degludec Irbesartan Avapro Increased risk of hypoglycemia Details Insulin Degludec Labetalol Normodyne® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Insulin Degludec Levobunolol Ophthalmic AKBeta® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Insulin Degludec Levothyroxine Ermeza Worsening of glycemic control Details Insulin Degludec Linezolid Injection Zyvox An increased risk of hypoglycemia Details Insulin Degludec Lithium Carbonate Lithobid Hypoglycemia or hyperglycemia Details Insulin Degludec Lixisenatide Injection Adlyxin® An increased risk of hypoglycemia Details Insulin Degludec Losartan Arbli Increased risk of hypoglycemia Details Insulin Degludec Mesalamine Apriso Increased risk of hypoglycemia Details Insulin Degludec Mesalamine Rectal Canasa Increased risk of hypoglycemia Details Insulin Degludec Moexipril Univasc® An increased risk of hypoglycemia Details Insulin Degludec Nadolol Corgard Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Insulin Degludec Nebivolol Bystolic Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Insulin Degludec Olmesartan Benicar Increased risk of hypoglycemia Details Insulin Degludec Penbutolol Levatol® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Insulin Degludec Perindopril Aceon An increased risk of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.