Insulin Degludec
75 interactions 3 explained in plain English
Also sold as:
Tresiba
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Orlistat
Miglitol
Gemifloxacin
Metoclopramide Nasal Spray
Metoclopramide Injection
Moxifloxacin Injection
Major
Insulin Degludec Acarbose Prandase® Explained An increased risk of hypoglycemia Details Insulin Degludec Abiraterone Abirtega An increased risk of severe hypoglycemia Details Insulin Degludec Alogliptin Nesina An increased risk of hypoglycemia Details Insulin Degludec Canagliflozin Invokana An increased risk of hypoglycemia Details Insulin Degludec Chloroquine Aralen® Hypoglycemia Details Insulin Degludec Dapagliflozin Farxiga An increased risk of hypoglycemia Details Insulin Degludec Delafloxacin Baxdela Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Insulin Degludec Delafloxacin Injection Baxdela Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Insulin Degludec Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) An increased risk of hypoglycemia Details Insulin Degludec Ertugliflozin Steglatro An increased risk of hypoglycemia Details Insulin Degludec Exenatide Injection Bydureon Increased risk of hypoglycemia Details Insulin Degludec Furosemide Injection Disal An increased risk of hyperglycemia and an increased insulin requirement Details Insulin Degludec Gatifloxacin Ophthalmic Zymar® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Insulin Degludec Gemifloxacin Factive Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Insulin Degludec Glimepiride Amaryl An increased risk of hypoglycemia Details Insulin Degludec Glipizide Glucotrol An increased risk of hypoglycemia Details Insulin Degludec Hydroxychloroquine Plaquenil Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Insulin Degludec Lanreotide Injection Somatuline An increased risk of hypoglycemia and impaired glucose regulation Details Insulin Degludec Levofloxacin Levaquin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Insulin Degludec Levofloxacin Injection Levaquin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Insulin Degludec Linagliptin Tradjenta An increased risk of hypoglycemia Details Insulin Degludec Liraglutide Injection Saxenda An increased risk of hypoglycemia Details Insulin Degludec Metformin Fortamet® An increased risk of hypoglycemia Details Insulin Degludec Metoclopramide Injection Gimoti Risk of hyperglycemia Details Insulin Degludec Metoclopramide Nasal Spray Gimoti Risk of hyperglycemia Details Insulin Degludec Miglitol Glyset® An increased risk of hypoglycemia Details Insulin Degludec Moxifloxacin Avelox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Insulin Degludec Moxifloxacin Injection Avelox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Insulin Degludec Moxifloxacin Ophthalmic Moxeza® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Insulin Degludec Nateglinide Starlix® An increased risk of hypoglycemia Details Insulin Degludec Octreotide Bynfezia An increased risk of hypoglycemia and impaired glucose regulation Details Insulin Degludec Octreotide Injection Bynfezia An increased risk of hypoglycemia and impaired glucose regulation Details Insulin Degludec Ofloxacin Floxin® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Insulin Degludec Ofloxacin Ophthalmic Ocuflox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Insulin Degludec Ofloxacin Otic Floxin® Otic Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Insulin Degludec Orlistat Alli An increased risk of hypoglycemia DetailsModerate
Insulin Degludec Lisinopril Prinivil Explained An increased risk of hypoglycemia Details Insulin Degludec Aspirin Acuprin® Increased risk of hypoglycemia Details Insulin Degludec Aspirin Rectal Aspirin Increased risk of hypoglycemia Details Insulin Degludec Atenolol Tenormin Explained Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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