Interferon Alfa-2B Injection and Vorasidenib: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Interferon Alfa-2B Injection
Vorasidenib
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased vorasidenib exposure and an increased risk of vorasidenib-related adverse reactions
Interaction Deep Dive
Avoid concomitant use of vorasidenib with a strong or moderate CYP1A2 inhibitor as it may increase vorasidenib exposure, which may increase the risk of adverse reactions. In drug interaction studies, concomitant use of ciprofloxacin (moderate CYP1A2 inhibitor) increased vorasidenib plasma Cmax 1.3-fold and AUC 2.5-fold. Also, concomitant use with fluvoxaMINE (strong CYP1A2 inhibitor) is predicted to increase vorasidenib Cmax and AUC greater than or equal to 5-fold. If concomitant use cannot be avoided, monitor for increased adverse reactions and modify the dosage for adverse reactions as necessary1.
Why it happens (mechanism)
Inhibition of CYP1A2-mediated metabolism of vorasidenib
Literature reports
1 report — tap to read
a) In drug interaction studies, concomitant use of ciprofloxacin (moderate CYP1A2 inhibitor) increased vorasidenib plasma Cmax 1.3-fold and AUC 2.5-fold. And concomitant use with fluvoxaMINE (strong CYP1A2 inhibitor) is predicted to increase vorasidenib Cmax and AUC greater than or equal to 5-fold 1.
Common questions
Can I take Interferon Alfa-2B Injection and Vorasidenib together?
Increased vorasidenib exposure and an increased risk of vorasidenib-related adverse reactions Always confirm with your pharmacist or prescriber before making any change.
How serious is the Interferon Alfa-2B Injection and Vorasidenib interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Interferon Alfa-2B Injection or Vorasidenib need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: VORANIGO® oral tablets, vorasidenib oral tablets. Servier Pharmaceuticals LLC (per FDA), Boston, MA, 2024. DailyMed
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