Interferon Alfa-2B Injection

13 interactions 282 cited references
Also sold as: Intron A®
About Interferon Alfa-2B Injection

Interferon alfa-2b injection is used to treat a number of conditions. Interferon alfa-2b injection is used alone or in combination with ribavirin (Copegus, Rebetol, Ribasphere) to treat chronic (long-term) hepatitis C infection (swelling of the liver caused by a virus) in people who show signs of liver damage, to treat… Read the full Interferon Alfa-2B Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Fezolinetant Bendamustine Clomipramine Clozapine Pimozide Pirfenidone
1 Contraindicated 9 Major 3 Moderate
All (13) Contraindicated (1) Major (9) Moderate (3)

Contraindicated

Interferon Alfa-2B Injection Fezolinetant Increased fezolinetant exposure Details

Major

Interferon Alfa-2B Injection Bendamustine Increased bendamustine exposure and an increased risk of bendamustine-related adverse effects Details Interferon Alfa-2B Injection Clomipramine Anafranil Increased clomiPRAMINE exposure Details Interferon Alfa-2B Injection Clozapine Clozaril Increased clozapine exposure Details Interferon Alfa-2B Injection Pimozide Increased pimozide exposure and an increased risk of pimozide-related adverse reactions Details Interferon Alfa-2B Injection Pirfenidone Esbriet Increased pirfenidone exposure Details Interferon Alfa-2B Injection Tizanidine Increased tiZANidine exposure and an increased risk of tiZANidine-related hypotension, bradycardia or increased drowsiness Details Interferon Alfa-2B Injection Triclabendazole Egaten Increased risk of QT interval prolongation Details Interferon Alfa-2B Injection Vorasidenib Voranigo Increased vorasidenib exposure and an increased risk of vorasidenib-related adverse reactions Details Interferon Alfa-2B Injection Warfarin Coumadin Increased warfarin exposure and an increased INR Details

Moderate

Interferon Alfa-2B Injection Propranolol Hemangeol Increased propranolol exposure Details Interferon Alfa-2B Injection Ribavirin Copegus® Worsening mental depression, anger, and hostility Details Interferon Alfa-2B Injection Theophylline Accurbron® Theophylline toxicity (nausea, vomiting, palpitations, seizures) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.