Irinotecan Injection and Oteseconazole: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Irinotecan Injection
Oteseconazole
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased exposure to BCRP substrates
Interaction Deep Dive
Oteseconazole, a BCRP inhibitor, increased the Cmax and AUC of rosuvastatin, a BCRP substrate, by 118% and 114%, respectively. Concomitant use of oteseconazole and BCRP substrates may increase the risk of adverse reactions associated with these drugs. Use the lowest possible starting dose of the BCRP substrate and consider reducing the dose of the substrate drug and monitor for adverse reactions1.
Why it happens (mechanism)
Inhibition of BCRP-mediated transport by oteseconazole
Literature reports
1 report — tap to read
a) Oteseconazole, a BCRP inhibitor, increased the Cmax and AUC(0 to 24 hours) of rosuvastatin, a BCRP substrate, by 118% and 114%, respectively 1.
Common questions
Can I take Irinotecan Injection and Oteseconazole together?
Increased exposure to BCRP substrates Always confirm with your pharmacist or prescriber before making any change.
How serious is the Irinotecan Injection and Oteseconazole interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Irinotecan Injection or Oteseconazole need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (2)
- Product Information: VIVJOA(TM) oral capsules, oteseconazole oral capsules. Mycovia Pharmaceuticals Inc (per manufacturer), Durham, NC, 2022. DailyMed
- Product Information: MOUNJARO(TM) subcutaneous injection, tirzepatide subcutaneous injection. Lilly USA LLC (per FDA), Indianapolis, IN, 2022. DailyMed
Keep reading about Irinotecan Injection
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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