Irinotecan Injection and Relacorilant: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Relacorilant
Irinotecan Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased CYP3A4 substrate exposure and an increased risk of CYP3A4-substrate-related adverse reactions
Interaction Deep Dive
Avoid concomitant use of relacorilant with CYP3A4 substrates, unless otherwise recommended. Concomitant use may increase the substrate exposure and the risk of adverse reactions of these substrates1.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated metabolism of relacorilant
Literature reports
1 report — tap to read
a) In drug interaction studies, coadministration of relacorilant, 350 mg under fasted condition (1.8 times the relacorilant exposure at the recommended dosage) once daily for 10 days with midazolam (CYP3A4 substrate) increased Cmax by 3.1-fold and AUC by 8.9-fold 1.
Common questions
Can I take Irinotecan Injection and Relacorilant together?
Increased CYP3A4 substrate exposure and an increased risk of CYP3A4-substrate-related adverse reactions Always confirm with your pharmacist or prescriber before making any change.
How serious is the Irinotecan Injection and Relacorilant interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Irinotecan Injection or Relacorilant need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: LIFYORLI™ oral capsules, relacorilant oral capsules. Corcept Therapeutics Incorporated (Per Manufacturer), Redwood City, CA, 2026. DailyMed
Keep reading about Relacorilant
Keep reading about Irinotecan Injection
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