Irinotecan Lipid Complex Injection and Lonafarnib: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Lonafarnib
Irinotecan Lipid Complex Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased irinotecan liposome exposure and an increased irinotecan liposome active metabolite exposure
Interaction Deep Dive
Avoid coadministration of irinotecan liposome (a CYP3A4 substrate) with a strong CYP3A4 inhibitor unless there are no therapeutic alternatives, as concomitant use may result in an increased exposure to irinotecan liposome or its active metabolite, SN-38. Discontinue strong CYP3A4 inhibitors at least 1 week prior to initiating therapy with irinotecan liposome12.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated metabolism of irinotecan liposome
Common questions
Can I take Irinotecan Lipid Complex Injection and Lonafarnib together?
Increased irinotecan liposome exposure and an increased irinotecan liposome active metabolite exposure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Irinotecan Lipid Complex Injection and Lonafarnib interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Irinotecan Lipid Complex Injection or Lonafarnib need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: ONIVYDE(R) intravenous injection, irinotecan liposome intravenous injection. Ipsen Biopharmaceuticals Inc (per FDA), Cambridge, MA, 2024. DailyMed
- Product Information: CAMPTOSAR(R) intravenous injection, irinotecan intravenous injection. Pharmacia & Upjohn Co (per Manufacturer), New York, NY, 2014. DailyMed
Keep reading about Lonafarnib
Keep reading about Irinotecan Lipid Complex Injection
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
Check another combination
Our instant two-drug interaction checker is almost here.
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacist