Isavuconazonium and Cyclosporine Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Isavuconazonium
Cyclosporine Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased cycloSPORINE exposure
Interaction Deep Dive
Concomitant use of isavuconazonium sulfate (prodrug of isavuconazole, mild P-gp inhibitor, and moderate CYP3A4 inhibitor) with cycloSPORINE (a CYP3A4 and P-gp substrate with a narrow therapeutic index) may increase the exposure of cycloSPORINE. During drug interaction studies, the systemic exposure of cycloSPORINE was increased in the presence of isavuconazole. If concomitant use is required, monitor drug levels of cycloSPORINE and adjust the dose of cycloSPORINE as needed1.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated metabolism of cycloSPORINE; inhibition of P-gp-mediated efflux transport of cycloSPORINE by isavuconazole
Literature reports
1 report — tap to read
a) During drug interaction studies, the systemic exposure of cycloSPORINE was increased in the presence of isavuconazole 1.
Common questions
Can I take Isavuconazonium and Cyclosporine Injection together?
Increased cycloSPORINE exposure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Isavuconazonium and Cyclosporine Injection interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Isavuconazonium or Cyclosporine Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: CRESEMBA(R) oral capsules, intravenous injection, isavuconazonium sulfate oral capsules, intravenous injection. Astellas Pharma US Inc (per FDA), Northbrook, IL, 2023. DailyMed
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Keep reading about Cyclosporine Injection
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