Isoniazid
25 interactions 1 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Glimepiride
Nifedipine
Mercaptopurine
Loperamide
Azathioprine
Methotrexate Injection
Major
Isoniazid Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of hepatotoxicity Details Isoniazid Acetaminophen Acephen An increased risk of hepatotoxicity Details Isoniazid Acetaminophen Injection Acephen An increased risk of hepatotoxicity Details Isoniazid Acetaminophen Rectal Acephen An increased risk of hepatotoxicity Details Isoniazid Azathioprine Azasan An increased risk of hepatotoxicity Details Isoniazid Diazepam Nasal Spray Valtoco Increased diazePAM exposure and increased risk of diazePAM toxicity (sedation, respiratory depression) Details Isoniazid Diazepam Rectal Diastat Increased diazePAM exposure and increased risk of diazePAM toxicity (sedation, respiratory depression) Details Isoniazid Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Isoniazid Glimepiride Amaryl Increased glimepiride exposure and risk of hypoglycemia Details Isoniazid Hydroxychloroquine Plaquenil An increased risk of seizures Details Isoniazid Ketoconazole Topical Extina® Foam Reduced ketoconazole exposure, reduced efficacy of ketoconazole and an increased risk of ketoconazole toxicity Details Isoniazid Levodopa Oral Inhalation Inbrija Excess catecholamine stimulation and/or reduced efficacy of levodopa, an increased risk of exacerbating psychosis (or symptoms of... Details Isoniazid Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Isoniazid Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Isoniazid Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Isoniazid Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Isoniazid Methylergonovine Methergine Increased methylergonovine exposure Details Isoniazid Nifedipine Adalat® Increased NIFEdipine exposure DetailsModerate
Isoniazid Clopidogrel Plavix Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Isoniazid Disulfiram Antabuse Increased risk of disulfiram CNS effects (changes in behavior, coordination, and mood) Details Isoniazid Dofetilide Tikosyn Increased dofetilide exposure Details Isoniazid Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details Isoniazid Hydrocortisone Ala-Cort Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Isoniazid Hydrocortisone Injection A-Hydrocort® Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Isoniazid Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control DetailsNo interactions on this page match that filter — try the next page or clear the filter.
Check another drug
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacistEducational information only, not medical advice. Always confirm interactions with your pharmacist
or prescriber before making any change to your medications.