Ivacaftor

Major

Ivacaftor Acetaminophen And Codeine Capital® & Codeine Explained Increased codeine and morphine exposure Details Ivacaftor Buprenorphine Belbuca Explained Increased buprenorphine exposure and an increased risk of buprenorphine-related adverse events Details Ivacaftor Relugolix Orgovyx Explained Increased relugolix exposure Details Ivacaftor Colchicine Colcrys Explained Increased P-gp/CYP3A substrate exposure Details Ivacaftor Belumosudil Rezurock Explained Reduced belumosudil exposure and reduced efficacy of belumosudil Details Ivacaftor Bedaquiline Sirturo Increased bedaquiline exposure Details Ivacaftor Budesonide Entocort Increased budesonide exposure Details Ivacaftor Budesonide Nasal Spray Rhinocort Increased budesonide exposure Details Ivacaftor Budesonide Oral Inhalation Pulmicort Increased budesonide exposure Details Ivacaftor Cyclosporine Injection Atopica Increased ivacaftor exposure and/or increased cycloSPORINE exposure Details Ivacaftor Cyclosporine Ophthalmic Cequa Increased ivacaftor exposure and/or increased cycloSPORINE exposure Details Ivacaftor Dabigatran Pradaxa® Increased dabigatran exposure and an increased risk of bleeding Details Ivacaftor Dabigatran Etexilate Increased dabigatran exposure and an increased risk of bleeding Details Ivacaftor Diazepam Nasal Spray Valtoco Increased benzodiazepine exposure and an increased risk of benzodiazepine-related adverse effects Details Ivacaftor Diazepam Rectal Diastat Increased benzodiazepine exposure and an increased risk of benzodiazepine-related adverse effects Details Ivacaftor Digoxin Cardoxin® Increased digoxin exposure Details Ivacaftor Dihydroergotamine Injection DHE-45® Injection Increased CYP3A substrate exposure Details Ivacaftor Dihydroergotamine Nasal Spray Migranal Increased CYP3A substrate exposure Details Ivacaftor Dofetilide Tikosyn Increased CYP3A substrate exposure Details Ivacaftor Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Ivacaftor Encorafenib Braftovi Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Ivacaftor Everolimus Afinitor Increased P-gp/CYP3A substrate exposure Details Ivacaftor Fentanyl Transdermal Patch Duragesic® Increased fentaNYL exposure and an increased risk of prolonged opioid effects Details Ivacaftor Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Ivacaftor Glimepiride Amaryl Increased glimepiride exposure Details Ivacaftor Glipizide Glucotrol Increased glipiZIDE exposure Details Ivacaftor Irinotecan Camptosar Reduced irinotecan exposure and reduced irinotecan active metabolite exposure Details Ivacaftor Irinotecan Injection Camptosar Reduced irinotecan exposure and reduced irinotecan active metabolite exposure Details Ivacaftor Irinotecan Lipid Complex Injection Onivyde® Reduced irinotecan exposure and reduced irinotecan active metabolite exposure Details Ivacaftor Ketoconazole Topical Extina® Foam Increased ivacaftor exposure Details Ivacaftor Lefamulin Xenleta Increased lefamulin exposure, an increased risk of lefamulin-related adverse reactions and increased sensitive CYP3A4 substrate ex... Details Ivacaftor Lenacapavir Injection Sunlenca Increased sensitive CYP3A substrate exposure and an increased risk of sensitive CYP3A substrate-mediated adverse reactions Details Ivacaftor Lenacapavir Oral Sunlenca Increased sensitive CYP3A substrate exposure and an increased risk of sensitive CYP3A substrate-mediated adverse reactions Details Ivacaftor Letermovir Injection Prevymis Increased ivacaftor exposure Details Ivacaftor Loperamide Diamode An increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Ivacaftor Macitentan Opsumit Reduced macitentan exposure Details Ivacaftor Methylergonovine Methergine Increased methylergonovine exposure Details Ivacaftor Midazolam Nasal Spray Nayzilam Increased benzodiazepine exposure and an increased risk of benzodiazepine-related adverse effects Details Ivacaftor Midazolam Injection Nayzilam Increased benzodiazepine exposure and an increased risk of benzodiazepine-related adverse effects Details Ivacaftor Mitapivat Aqvesme Reduced CYP3A substrate exposure Details