Ketamine

28 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Nalbuphine Injection Metoclopramide Nasal Spray Esketamine Nasal Spray Asenapine Transdermal Patch Hydromorphone Injection Levodopa Oral Inhalation
27 Major 1 Moderate
All (28) Major (27) Moderate (1)

Major

Ketamine Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Ketamine Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Ketamine Aripiprazole Injection Abilify Increased risk of respiratory and CNS depression Details Ketamine Asenapine Transdermal Patch Secuado Increased risk of respiratory and CNS depression Details Ketamine Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Ketamine Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Ketamine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Ketamine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Ketamine Diazepam Nasal Spray Valtoco Increased risk of respiratory and CNS depression Details Ketamine Diazepam Rectal Diastat Increased risk of respiratory and CNS depression Details Ketamine Diphenhydramine Injection Banophen Increased risk of respiratory and CNS depression Details Ketamine Diphenhydramine Topical Afterbite with Antihistamine Increased risk of respiratory and CNS depression Details Ketamine Esketamine Nasal Spray Spravato Increased risk of respiratory and CNS depression Details Ketamine Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Ketamine Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Ketamine Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Ketamine Hydroxychloroquine Plaquenil An increased risk of seizures Details Ketamine Lacosamide Injection Motpoly An increased risk of CNS depression Details Ketamine Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Ketamine Levothyroxine Ermeza An increased risk of marked hypertension and tachycardia Details Ketamine Memantine Namenda Increased adverse events of N-methyl-D-aspartate antagonists Details Ketamine Metoclopramide Injection Gimoti Increased risk of CNS depression Details Ketamine Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Ketamine Midazolam Nasal Spray Nayzilam Increased risk of respiratory and CNS depression Details Ketamine Midazolam Injection Nayzilam Increased risk of respiratory and CNS depression Details Ketamine Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Ketamine Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.