Ketoprofen and Dicumarol: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Ketoprofen
Dicumarol
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of bleeding
Interaction Deep Dive
Previous data has indicated that concomitant warfarin and ketoprofen therapy has not resulted in interference with warfarin effects on prothrombin time in healthy subjects123. Since ketoprofen can decrease platelet adhesion, platelet aggregation, and cause gastric erosion, concurrent therapy with ketoprofen and oral anticoagulants requires close monitoring of coagulation parameters and bleeding complications 1.
Why it happens (mechanism)
Inhibition of platelet aggregation, gastric erosion
Common questions
Can I take Ketoprofen and Dicumarol together?
An increased risk of bleeding Always confirm with your pharmacist or prescriber before making any change.
How serious is the Ketoprofen and Dicumarol interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "delayed". Effects tend to build up gradually over days to weeks.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Ketoprofen or Dicumarol need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (3)
- Product Information: Orudis(R), ketoprofen. Wyeth Laboratories, Philadelphia, PA, 1998. DailyMed
- Kantor T: Ketoprofen: a review of its pharmacologic and clinical properties. Pharmacotherapy 1986; 6:93-103. PubMed
- Mieszczak C & Winther K: Lack of interaction of ketoprofen with warfarin. Eur J Clin Pharmacol 1993; 44:205-206. PubMed
Keep reading about Ketoprofen
Keep reading about Dicumarol
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