Ketoprofen

289 interactions 429 cited references
Also sold as: Actron® Ketofen Ketomed Kiprofen Nexcede® Orudis Orudis® Orudis® KT Oruvail®
About Ketoprofen

Prescription ketoprofen is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). Prescription ketoprofen capsules are also used to relieve pain,… Read the full Ketoprofen drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Nasal Spray Ketorolac Ketorolac Ophthalmic Ketorolac Injection Eplerenone Pemetrexed Injection
4 Contraindicated 226 Major 59 Moderate
All (289) Contraindicated (4) Major (226) Moderate (59)

Contraindicated

Ketoprofen Ketorolac Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketoprofen Ketorolac Injection Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketoprofen Ketorolac Nasal Spray Sprix Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketoprofen Ketorolac Ophthalmic Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details

Major

Ketoprofen Amitriptyline Elavil An increased risk of bleeding Details Ketoprofen Sertraline An increased risk of bleeding Details Ketoprofen Apixaban Eliquis An increased risk of bleeding Details Ketoprofen Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Ketoprofen Aspirin Rectal Aspirin An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Ketoprofen Betrixaban Bevyxxa® An increased risk of bleeding Details Ketoprofen Anagrelide Agrylin An increased risk of bleeding Details Ketoprofen Bromfenac Ophthalmic Bromday® Increased risk of bleeding Details Ketoprofen Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Ketoprofen Budesonide Nasal Spray Rhinocort Increased risk of gastrointestinal ulcer or bleeding Details Ketoprofen Budesonide Oral Inhalation Pulmicort Increased risk of gastrointestinal ulcer or bleeding Details Ketoprofen Clopidogrel Plavix An increased risk of bleeding Details Ketoprofen Cyclosporine Injection Atopica An increased risk of cycloSPORINE nephrotoxicity Details Ketoprofen Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE nephrotoxicity Details Ketoprofen Dabigatran Pradaxa® An increased risk of bleeding Details Ketoprofen Dabigatran Etexilate An increased risk of bleeding Details Ketoprofen Dalteparin Injection Fragmin An increased risk of bleeding Details Ketoprofen Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Ketoprofen Dexamethasone Injection Decadron Increased risk of gastrointestinal ulcer or bleeding Details Ketoprofen Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal ulcer or bleeding Details Ketoprofen Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of bleeding Details Ketoprofen Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of bleeding Details Ketoprofen Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of bleeding Details Ketoprofen Diclofenac Transdermal Patch Flector Increased risk of bleeding Details Ketoprofen Digoxin Cardoxin® Increased digoxin exposure and prolonged half-life of digoxin Details Ketoprofen Dipyridamole Permole® An increased risk of bleeding Details Ketoprofen Edoxaban Savaysa An increased risk of bleeding Details Ketoprofen Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Ketoprofen Enoxaparin Lovenox An increased risk of bleeding Details Ketoprofen Enoxaparin Injection Lovenox An increased risk of bleeding Details Ketoprofen Epoprostenol Flolan An increased risk of bleeding Details Ketoprofen Etodolac Lodine Increased risk of bleeding Details Ketoprofen Fenoprofen Fenopron Increased risk of bleeding Details Ketoprofen Flurbiprofen Ansaid Increased risk of bleeding Details Ketoprofen Flurbiprofen Ophthalmic Ocufen Increased risk of bleeding Details Ketoprofen Fondaparinux Arixtra An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.