Ketorolac Ophthalmic

246 interactions 464 cited references

Also sold as: Acular Acular® Acuvail Acuvail®

About Ketorolac Ophthalmic

Ophthalmic ketorolac is used to treat itchy eyes caused by allergies. It also is used to treat swelling and redness (inflammation) that can occur after cataract surgery. Ketorolac is in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by stopping the release of substances that cause… Read the full Ketorolac Ophthalmic drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Fenoprofen Flurbiprofen Fepradinol Feprazone Floctafenine Flufenamic Acid

64 Contraindicated 129 Major 53 Moderate

All (246) Contraindicated (64) Major (129) Moderate (53)

Major

Ketorolac Ophthalmic Dibenzepin An increased risk of bleeding Details Ketorolac Ophthalmic Digoxin Cardoxin® Increased digoxin exposure and prolonged half-life of digoxin Details Ketorolac Ophthalmic Dipyridamole Permole® An increased risk of bleeding Details Ketorolac Ophthalmic Dothiepin An increased risk of bleeding Details Ketorolac Ophthalmic Doxepin Prudoxin An increased risk of bleeding Details Ketorolac Ophthalmic Duloxetine An increased risk of bleeding Details Ketorolac Ophthalmic Edoxaban Savaysa An increased risk of bleeding Details Ketorolac Ophthalmic Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Ketorolac Ophthalmic Enoxaparin Lovenox An increased risk of bleeding Details Ketorolac Ophthalmic Eplerenone Inspra Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Ketorolac Ophthalmic Epoprostenol Flolan An increased risk of bleeding Details Ketorolac Ophthalmic Eptifibatide An increased risk of bleeding Details Ketorolac Ophthalmic Escitalopram Lexapro An increased risk of bleeding Details Ketorolac Ophthalmic Ethacrynic Acid Edecrin Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Ophthalmic Etozolin Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Ophthalmic Feverfew Increased risk of adverse effects from the nonsteroidal antiinflammatory agent (ie, gastrointestinal, renal effects) Details Ketorolac Ophthalmic Fluoxetine RECONCILE An increased risk of bleeding Details Ketorolac Ophthalmic Fluvoxamine An increased risk of bleeding Details Ketorolac Ophthalmic Fondaparinux Arixtra An increased risk of bleeding Details Ketorolac Ophthalmic Furosemide Disal Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Ophthalmic Gossypol Increased risk of adverse gastrointestinal effects Details Ketorolac Ophthalmic Heparin An increased risk of bleeding Details Ketorolac Ophthalmic Hydrochlorothiazide Inzirqo Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Ophthalmic Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Ketorolac Ophthalmic Hydroflumethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Ophthalmic Iloprost Aurlumyn An increased risk of bleeding Details Ketorolac Ophthalmic Imipramine An increased risk of bleeding Details Ketorolac Ophthalmic Indapamide Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Ophthalmic Inotersen Increased risk of bleeding Details Ketorolac Ophthalmic Lepirudin An increased risk of bleeding Details Ketorolac Ophthalmic Levomilnacipran An increased risk of bleeding Details Ketorolac Ophthalmic Lithium Increased lithium exposure and an increased risk of lithium toxicity Details Ketorolac Ophthalmic Lofepramine An increased risk of bleeding Details Ketorolac Ophthalmic Meadowsweet Increased risk of bleeding Details Ketorolac Ophthalmic Melitracen An increased risk of bleeding Details Ketorolac Ophthalmic Melphalan Alkeran An increased risk of bleeding Details Ketorolac Ophthalmic Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Ketorolac Ophthalmic Methyclothiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Ophthalmic Methylprednisolone Depo-Medrol Increased risk of gastrointestinal ulcer or bleeding Details Ketorolac Ophthalmic Metolazone Reduced diuretic effectiveness and possible nephrotoxicity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.