Ketorolac Ophthalmic

246 interactions 464 cited references

Also sold as: Acular Acular® Acuvail Acuvail®

About Ketorolac Ophthalmic

Ophthalmic ketorolac is used to treat itchy eyes caused by allergies. It also is used to treat swelling and redness (inflammation) that can occur after cataract surgery. Ketorolac is in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by stopping the release of substances that cause… Read the full Ketorolac Ophthalmic drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Fenoprofen Flurbiprofen Fepradinol Feprazone Floctafenine Flufenamic Acid

64 Contraindicated 129 Major 53 Moderate

All (246) Contraindicated (64) Major (129) Moderate (53)

Major

Ketorolac Ophthalmic Milnacipran Savella An increased risk of bleeding Details Ketorolac Ophthalmic Nadroparin An increased risk of bleeding Details Ketorolac Ophthalmic Nefazodone An increased risk of bleeding Details Ketorolac Ophthalmic Nortriptyline An increased risk of bleeding Details Ketorolac Ophthalmic Opipramol An increased risk of bleeding Details Ketorolac Ophthalmic Parnaparin An increased risk of bleeding Details Ketorolac Ophthalmic Paroxetine Paxil An increased risk of bleeding Details Ketorolac Ophthalmic Pemetrexed Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Ketorolac Ophthalmic Pentosan Polysulfate Sodium An increased risk of bleeding Details Ketorolac Ophthalmic Phenindione An increased risk of bleeding Details Ketorolac Ophthalmic Phenprocoumon An increased risk of bleeding Details Ketorolac Ophthalmic Piretanide Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Ophthalmic Polythiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Ophthalmic Potassium Citrate Urocit-K Increased risk of hyperkalemia Details Ketorolac Ophthalmic Prasugrel Effient An increased risk of bleeding Details Ketorolac Ophthalmic Prednisolone Flo-Pred® Increased risk of gastrointestinal ulcer or bleeding Details Ketorolac Ophthalmic Prednisone Deltasone Increased risk of gastrointestinal ulcer or bleeding Details Ketorolac Ophthalmic Protein C Ceprotin An increased risk of bleeding Details Ketorolac Ophthalmic Protriptyline An increased risk of bleeding Details Ketorolac Ophthalmic Quinethazone Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Ophthalmic Reviparin An increased risk of bleeding Details Ketorolac Ophthalmic Rivaroxaban Xarelto An increased risk of bleeding Details Ketorolac Ophthalmic Selexipag Uptravi An increased risk of bleeding Details Ketorolac Ophthalmic Sertraline An increased risk of bleeding Details Ketorolac Ophthalmic Sibutramine An increased risk of bleeding Details Ketorolac Ophthalmic Spironolactone Aldactone Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Ketorolac Ophthalmic Sulfinpyrazone An increased risk of bleeding Details Ketorolac Ophthalmic Sulodexide An increased risk of bleeding Details Ketorolac Ophthalmic Tacrolimus Astagraf Acute renal failure Details Ketorolac Ophthalmic Tenofovir Alafenamide Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Ketorolac Ophthalmic Tenofovir Disoproxil Fumarate Increased risk of acute renal failure Details Ketorolac Ophthalmic Tianeptine An increased risk of bleeding Details Ketorolac Ophthalmic Ticagrelor Brilinta An increased risk of bleeding Details Ketorolac Ophthalmic Ticlopidine Ticlid® An increased risk of bleeding Details Ketorolac Ophthalmic Tinzaparin An increased risk of bleeding Details Ketorolac Ophthalmic Tirofiban An increased risk of bleeding Details Ketorolac Ophthalmic Torsemide Soaanz Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Ophthalmic Trazodone Raldesy An increased risk of bleeding Details Ketorolac Ophthalmic Treprostinil Orenitram An increased risk of bleeding Details Ketorolac Ophthalmic Triamterene Dyrenium Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.