Ketorolac Ophthalmic

246 interactions 464 cited references
Also sold as: Acular Acular® Acuvail Acuvail®
About Ketorolac Ophthalmic

Ophthalmic ketorolac is used to treat itchy eyes caused by allergies. It also is used to treat swelling and redness (inflammation) that can occur after cataract surgery. Ketorolac is in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by stopping the release of substances that cause… Read the full Ketorolac Ophthalmic drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Fenoprofen Flurbiprofen Fepradinol Feprazone Floctafenine Flufenamic Acid
64 Contraindicated 129 Major 53 Moderate
All (246) Contraindicated (64) Major (129) Moderate (53)

Major

Ketorolac Ophthalmic Prednisone Deltasone Increased risk of gastrointestinal ulcer or bleeding Details Ketorolac Ophthalmic Protein C Ceprotin An increased risk of bleeding Details Ketorolac Ophthalmic Protriptyline An increased risk of bleeding Details Ketorolac Ophthalmic Quinethazone Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Ophthalmic Reviparin An increased risk of bleeding Details Ketorolac Ophthalmic Rivaroxaban Xarelto An increased risk of bleeding Details Ketorolac Ophthalmic Selexipag Uptravi An increased risk of bleeding Details Ketorolac Ophthalmic Sertraline An increased risk of bleeding Details Ketorolac Ophthalmic Sibutramine An increased risk of bleeding Details Ketorolac Ophthalmic Spironolactone Aldactone Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Ketorolac Ophthalmic Sulfinpyrazone An increased risk of bleeding Details Ketorolac Ophthalmic Sulodexide An increased risk of bleeding Details Ketorolac Ophthalmic Tacrolimus Astagraf Acute renal failure Details Ketorolac Ophthalmic Tenofovir Alafenamide Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Ketorolac Ophthalmic Tenofovir Disoproxil Fumarate Increased risk of acute renal failure Details Ketorolac Ophthalmic Tianeptine An increased risk of bleeding Details Ketorolac Ophthalmic Ticagrelor Brilinta An increased risk of bleeding Details Ketorolac Ophthalmic Ticlopidine Ticlid® An increased risk of bleeding Details Ketorolac Ophthalmic Tinzaparin An increased risk of bleeding Details Ketorolac Ophthalmic Tirofiban An increased risk of bleeding Details Ketorolac Ophthalmic Torsemide Soaanz Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Ophthalmic Trazodone Raldesy An increased risk of bleeding Details Ketorolac Ophthalmic Treprostinil Orenitram An increased risk of bleeding Details Ketorolac Ophthalmic Triamterene Dyrenium Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Ketorolac Ophthalmic Trichlormethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Ophthalmic Trimipramine An increased risk of bleeding Details Ketorolac Ophthalmic Upadacitinib Rinvoq Increased risk of gastrointestinal perforations Details Ketorolac Ophthalmic Venlafaxine An increased risk of bleeding Details Ketorolac Ophthalmic Vilazodone Viibryd An increased risk of bleeding Details Ketorolac Ophthalmic Vorapaxar Zontivity An increased risk of bleeding Details Ketorolac Ophthalmic Vortioxetine Trintellix An increased risk of bleeding Details Ketorolac Ophthalmic Warfarin Coumadin An increased risk of bleeding Details Ketorolac Ophthalmic Xipamide Reduced diuretic effectiveness and possible nephrotoxicity Details

Moderate

Ketorolac Ophthalmic Acebutolol Sectral® Reduced antihypertensive effect Details Ketorolac Ophthalmic Anisindione An increased risk of bleeding Details Ketorolac Ophthalmic Atenolol Tenormin Reduced antihypertensive effect Details Ketorolac Ophthalmic Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ketorolac Ophthalmic Azilsartan Medoxomil Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ketorolac Ophthalmic Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ketorolac Ophthalmic Betaxolol Betoptic S Reduced antihypertensive effect Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.