Lacosamide
49 interactions 4 explained in plain English
Also sold as:
Motpoly
Vimpat
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Cetirizine Injection
Hydroxychloroquine
Hydromorphone Injection
Amlodipine
Asenapine Transdermal Patch
Nadolol
Major
Lacosamide Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of CNS depression Details Lacosamide Amitriptyline Elavil Explained An increased risk of PR interval prolongation, AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Buprenorphine Belbuca Explained An increased risk of CNS depression Details Lacosamide Aripiprazole Injection Abilify An increased risk of CNS depression Details Lacosamide Asenapine Transdermal Patch Secuado An increased risk of CNS depression Details Lacosamide Atenolol Tenormin Explained An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Acebutolol Sectral® An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Amlodipine Amvaz® An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Betaxolol Betoptic S An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Betaxolol Ophthalmic Betoptic® An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Bisoprolol Zebeta® An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Butorphanol Injection Butorphic An increased risk of CNS depression Details Lacosamide Butorphanol Nasal Spray Stadol® NS An increased risk of CNS depression Details Lacosamide Calcifediol Rayaldee Altered serum levels of calcifediol Details Lacosamide Cetirizine Injection Aller-Tec An increased risk of CNS depression Details Lacosamide Cetirizine Ophthalmic Zerviate An increased risk of CNS depression Details Lacosamide Diazepam Nasal Spray Valtoco An increased risk of CNS depression Details Lacosamide Diazepam Rectal Diastat An increased risk of CNS depression Details Lacosamide Diphenhydramine Injection Banophen An increased risk of CNS depression Details Lacosamide Diphenhydramine Topical Afterbite with Antihistamine An increased risk of CNS depression Details Lacosamide Disopyramide Norpace An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Dofetilide Tikosyn An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Dolasetron Anzemet An increased risk of PR interval prolongation, AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Dolasetron Injection Anzemet An increased risk of PR interval prolongation, AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Esketamine Nasal Spray Spravato An increased risk of CNS depression Details Lacosamide Esmolol Brevibloc An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Felodipine Plendil® An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Fentanyl Transdermal Patch Duragesic® An increased risk of CNS depression Details Lacosamide Flecainide Tambocor® An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Hydromorphone Injection Dilaudid An increased risk of CNS depression Details Lacosamide Hydromorphone Rectal available generically An increased risk of CNS depression Details Lacosamide Hydroxychloroquine Plaquenil Impaired antiepileptic activity Details Lacosamide Isradipine DynaCirc® An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Labetalol Normodyne® An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Levobunolol Ophthalmic AKBeta® An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Mexiletine Mexitil® An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Midazolam Nasal Spray Nayzilam An increased risk of CNS depression Details Lacosamide Midazolam Injection Nayzilam An increased risk of CNS depression Details Lacosamide Morphine Injection Astramorph® PF An increased risk of CNS depression Details Lacosamide Nadolol Corgard An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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