Landiolol and Nicardipine: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Nicardipine
Landiolol
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of myocardial contractility depression and increase the risk of bradycardia or heart block
Interaction Deep Dive
Avoid concomitant use of landiolol with negative inotropes/chronotropes and medications that slow heart rate or cardiac conduction, like calcium channel blockers. Concomitant use of landiolol with negative inotropes or chronotropes may augment the risk of depression of myocardial contractility and increase the risk of bradycardia or heart block1.
Why it happens (mechanism)
Additive cardiovascular effects
Common questions
Can I take Landiolol and Nicardipine together?
An increased risk of myocardial contractility depression and increase the risk of bradycardia or heart block Always confirm with your pharmacist or prescriber before making any change.
How serious is the Landiolol and Nicardipine interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Landiolol or Nicardipine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: RAPIBLYK intravenous injection lyophilized powder for solution, landiolol intravenous injection lyophilized powder for solution. AOP Orphan Pharmaceuticals GmbH (per FDA), 2024. DailyMed
Keep reading about Nicardipine
Keep reading about Landiolol
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