Lemborexant

67 interactions 6 explained in plain English
Also sold as: Dayvigo
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Lemborexant Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of CNS depression and potential next-day somnolence Details Lemborexant Abametapir Explained Increased exposure of CYP3A4 substrate Details Lemborexant Amitriptyline Elavil Explained An increased risk of CNS depression and potential next-day somnolence Details Lemborexant Buprenorphine Belbuca Explained An increased risk of CNS depression and potential next-day somnolence Details Lemborexant Aripiprazole Injection Abilify An increased risk of CNS depression and potential next-day somnolence Details Lemborexant Asciminib Scemblix Increased lemborexant exposure and an increased risk of lemborexant-related adverse reactions. Details Lemborexant Asenapine Transdermal Patch Secuado An increased risk of CNS depression and potential next-day somnolence Details Lemborexant Azithromycin AzaSite Increased lemborexant exposure and an increased risk of lemborexant-related adverse reactions. Details Lemborexant Belumosudil Rezurock Explained Increased lemborexant exposure and an increased risk of lemborexant-related adverse reactions. Details Lemborexant Bicalutamide Casodex Increased lemborexant exposure and an increased risk of lemborexant-related adverse reactions. Details Lemborexant Atorvastatin Atorvaliq Increased lemborexant exposure and an increased risk of lemborexant-related adverse reactions. Details Lemborexant Amlodipine Amvaz® Increased lemborexant exposure and an increased risk of lemborexant-related adverse reactions. Details Lemborexant Brodalumab Injection Siliq Increased lemborexant exposure and an increased risk of lemborexant-related adverse reactions. Details Lemborexant Butorphanol Injection Butorphic An increased risk of CNS depression and potential next-day somnolence Details Lemborexant Butorphanol Nasal Spray Stadol® NS An increased risk of CNS depression and potential next-day somnolence Details Lemborexant Cetirizine Injection Aller-Tec An increased risk of CNS depression and potential next-day somnolence Details Lemborexant Cetirizine Ophthalmic Zerviate An increased risk of CNS depression and potential next-day somnolence Details Lemborexant Clotrimazole Aardora Anti-Fungal Maximum Strength Increased lemborexant exposure and an increased risk of lemborexant-related adverse reactions. Details Lemborexant Clotrimazole Lozenge Mycelex® Increased lemborexant exposure and an increased risk of lemborexant-related adverse reactions. Details Lemborexant Clotrimazole Topical Cruex Antifungal Increased lemborexant exposure and an increased risk of lemborexant-related adverse reactions. Details Lemborexant Clotrimazole Vaginal Gyne-Lotrimin 3® Cream Increased lemborexant exposure and an increased risk of lemborexant-related adverse reactions. Details Lemborexant Cyclophosphamide Cytoxan® Reduced CYP2B6 substrates exposure and reduced efficacy of CYP2B6 substrates Details Lemborexant Cyclophosphamide Injection Cytoxan® Injection Reduced CYP2B6 substrates exposure and reduced efficacy of CYP2B6 substrates Details Lemborexant Cyclosporine Injection Atopica Increased lemborexant exposure and an increased risk of lemborexant-related adverse reactions. Details Lemborexant Cyclosporine Ophthalmic Cequa Increased lemborexant exposure and an increased risk of lemborexant-related adverse reactions. Details Lemborexant Diazepam Nasal Spray Valtoco An increased risk of CNS depression and potential next-day somnolence Details Lemborexant Diazepam Rectal Diastat An increased risk of CNS depression and potential next-day somnolence Details Lemborexant Diphenhydramine Injection Banophen An increased risk of CNS depression and potential next-day somnolence Details Lemborexant Diphenhydramine Topical Afterbite with Antihistamine An increased risk of CNS depression and potential next-day somnolence Details Lemborexant Encorafenib Braftovi Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Lemborexant Entrectinib Rozlytrek Increased lemborexant exposure and an increased risk of lemborexant-related adverse reactions. Details Lemborexant Erdafitinib Balversa Increased lemborexant exposure and an increased risk of lemborexant-related adverse reactions. Details Lemborexant Esketamine Nasal Spray Spravato An increased risk of CNS depression and potential next-day somnolence, an increased lemborexant exposure, an increased risk of lem... Details Lemborexant Esomeprazole Nexium Increased lemborexant exposure and an increased risk of lemborexant-related adverse reactions. Details Lemborexant Esomeprazole Injection Nexium Increased lemborexant exposure and an increased risk of lemborexant-related adverse reactions. Details Lemborexant Estradiol Delestrogen Increased lemborexant exposure and an increased risk of lemborexant-related adverse reactions. Details Lemborexant Estradiol Topical Divigel Increased lemborexant exposure and an increased risk of lemborexant-related adverse reactions. Details Lemborexant Estradiol Transdermal Patch Alora® Increased lemborexant exposure and an increased risk of lemborexant-related adverse reactions. Details Lemborexant Everolimus Afinitor Increased lemborexant exposure and an increased risk of lemborexant-related adverse reactions. Details Lemborexant Fentanyl Transdermal Patch Duragesic® An increased risk of CNS depression and potential next-day somnolence Details

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