Lenacapavir

Name: Lenacapavir Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

75 interactions 8 explained in plain English

Also sold as: Sunlenca Yeztugo

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Colchicine Encorafenib Letermovir Injection Nisoldipine Nafcillin Injection Lefamulin

2 Contraindicated 72 Major 1 Moderate

All (75) Contraindicated (2) Major (72) Moderate (1)

Contraindicated

Lenacapavir Colchicine Colcrys Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Lenacapavir Encorafenib Braftovi Reduced lenacapavir exposure which may result in the loss of therapeutic effect and development of resistance to lenacapavir Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.