Lepirudin

53 interactions 2 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Defibrotide Injection Orlistat Meloxicam Mefenamic Acid Diclofenac Topical (Actinic Keratosis) Epoprostenol

1 Contraindicated 47 Major 5 Moderate

All (53) Contraindicated (1) Major (47) Moderate (5)

Contraindicated

Lepirudin Defibrotide Injection Defitelio Increased risk of bleeding Details

Major

Lepirudin Sertraline Explained An increased risk of bleeding Details Lepirudin Apixaban Eliquis Explained An increased risk of bleeding and can cause serious, potentially fatal bleeding Details Lepirudin Aspirin Acuprin® Increased risk of bleeding Details Lepirudin Aspirin Rectal Aspirin Increased risk of bleeding Details Lepirudin Betrixaban Bevyxxa® Increased risk of bleeding Details Lepirudin Anagrelide Agrylin Increased risk of bleeding Details Lepirudin Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Lepirudin Caplacizumab-Yhdp Injection Cablivi An increased risk of bleeding Details Lepirudin Clopidogrel Plavix Increased risk of bleeding Details Lepirudin Dabigatran Pradaxa® An increased risk of bleeding Details Lepirudin Dabigatran Etexilate An increased risk of bleeding Details Lepirudin Dalteparin Injection Fragmin Increased risk of bleeding Details Lepirudin Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Lepirudin Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Lepirudin Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Lepirudin Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Lepirudin Dipyridamole Permole® Increased risk of bleeding Details Lepirudin Doxycycline Injection Acticlate An increased risk of bleeding Details Lepirudin Edoxaban Savaysa Increased risk of bleeding Details Lepirudin Enoxaparin Lovenox Increased risk of bleeding Details Lepirudin Enoxaparin Injection Lovenox Increased risk of bleeding Details Lepirudin Epoprostenol Flolan Increased risk of bleeding Details Lepirudin Etodolac Lodine An increased risk of bleeding Details Lepirudin Fenoprofen Fenopron An increased risk of bleeding Details Lepirudin Flurbiprofen Ansaid An increased risk of bleeding Details Lepirudin Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details Lepirudin Ibrutinib Imbruvica Increased risk of bleeding Details Lepirudin Ibuprofen Addaprin An increased risk of bleeding Details Lepirudin Iloprost Aurlumyn Increased risk of bleeding Details Lepirudin Ketoprofen Actron® An increased risk of bleeding Details Lepirudin Ketorolac Acular An increased risk of bleeding Details Lepirudin Ketorolac Injection Acular An increased risk of bleeding Details Lepirudin Ketorolac Nasal Spray Sprix An increased risk of bleeding Details Lepirudin Ketorolac Ophthalmic Acular An increased risk of bleeding Details Lepirudin Lecanemab-Irmb Injection Leqembi An increased risk of amyloid related imaging abnormalities (ARIA), or intracerebral hemorrhage Details Lepirudin Meclofenamate Meclodium® An increased risk of bleeding Details Lepirudin Mefenamic Acid Ponstel® An increased risk of bleeding Details Lepirudin Meloxicam Alloxate An increased risk of bleeding Details Lepirudin Meloxicam Injection Alloxate An increased risk of bleeding Details

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