Lepirudin

Name: Lepirudin Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

53 interactions 2 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Defibrotide Injection Orlistat Meloxicam Mefenamic Acid Diclofenac Topical (Actinic Keratosis) Epoprostenol

1 Contraindicated 47 Major 5 Moderate

All (53) Contraindicated (1) Major (47) Moderate (5)

Major

Lepirudin Minocycline Amzeeq An increased risk of bleeding Details Lepirudin Minocycline Topical Amzeeq An increased risk of bleeding Details Lepirudin Nabumetone Relafen An increased risk of bleeding Details Lepirudin Naproxen Aleve An increased risk of bleeding Details Lepirudin Nintedanib Ofev Increased risk of bleeding Details Lepirudin Omadacycline Nuzyra Increased risk of bleeding Details Lepirudin Omadacycline Injection Nuzyra Increased risk of bleeding Details Lepirudin Orlistat Alli An increased risk of bleeding Details

Moderate

Lepirudin Capsaicin Arthricare for Women Moisturizing Increased risk of bleeding Details Lepirudin Capsaicin Topical Aspercreme Warming® Increased risk of bleeding Details Lepirudin Capsaicin Transdermal Patch Aspercreme Warming® Patch Increased risk of bleeding Details Lepirudin Ibritumomab Injection Zevalin® An increased risk of bleeding and hemorrhage Details Lepirudin Icosapent Ethyl Vascepa An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.