Letermovir Injection and Gepotidacin: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Letermovir Injection
Gepotidacin
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased gepotidacin exposure
Interaction Deep Dive
Avoid concomitant use of gepotidacin with moderate CYP3A4 inhibitors for the treatment of uncomplicated urogenital gonorrhea as it may increase the exposure of gepotidacin. No dosage adjustment required for the treatment of uncomplicated urinary tract infections (uUTI)1.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated metabolism of gepotidacin
Literature reports
1 report — tap to read
a) In a drug interaction study, concomitant use of a moderate CYP3A4 inhibitor (fluconazole) and single 1,500 mg dose of gepotidacin is predicted to increase gepotidacin Cmax by 1.3-fold and AUC by 1.5-fold 1.
Common questions
Can I take Letermovir Injection and Gepotidacin together?
Increased gepotidacin exposure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Letermovir Injection and Gepotidacin interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Letermovir Injection or Gepotidacin need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: BLUJEPA oral tablets, gepotidacin oral tablets. GlaxoSmithKline (per FDA), Durham, NC, 2025. DailyMed
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