Levoketoconazole

185 interactions 11 explained in plain English

Also sold as: Recorlev Recorlev®

About Levoketoconazole

Levoketoconazole is used to treat high levels of cortisol (a hormone produced by your adrenal glands) in patients with Cushing's syndrome (a condition in which the body produces too much cortisol) and who have failed surgery or cannot have surgery to treat this condition. Levoketoconazole is in a class of medications c… Read the full Levoketoconazole drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Metronidazole Injection Mefloquine Hydroxychloroquine Oxaliplatin Injection Clindamycin Topical Chloroquine

103 Contraindicated 82 Major

All (185) Contraindicated (103) Major (82)

Major

Levoketoconazole Etodolac Lodine Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Febuxostat Uloric Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Fenoprofen Fenopron Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Flutamide Eulexin Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Fulvestrant Faslodex Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Fulvestrant Injection Faslodex Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Ganciclovir Cytovene® Oral Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Ganciclovir Injection Cytovene® I.V.® Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Ganciclovir Ophthalmic Zirgan Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Gemcitabine Avgemsi Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Gemcitabine Injection Avgemsi Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Gemtuzumab Ozogamicin Injection Mylotarg Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Glimepiride Amaryl Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Golimumab Injection Simponi Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Hydroxyurea Droxia Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Interferon Beta-1A Intramuscular Injection Avonex Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Interferon Beta-1A Subcutaneous Injection Avonex Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Interferon Beta-1B Injection Betaseron Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Ixabepilone Injection IXEMPRA Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Labetalol Normodyne® Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Lansoprazole Prevacid Reduced levoketoconazole exposure Details Levoketoconazole Leflunomide Arava Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Levetiracetam Elepsia Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Levetiracetam Injection Elepsia Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Mefenamic Acid Ponstel® Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Memantine Namenda Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Mercaptopurine Purinethol® Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Mesalamine Apriso Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Mesalamine Rectal Canasa Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Metformin Fortamet® Increased metFORMIN exposure and an increased risk of metFORMIN-related adverse effects Details Levoketoconazole Methazolamide Neptazane® Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Methimazole Felanorm Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Minocycline Amzeeq Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Minocycline Topical Amzeeq Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Nevirapine Viramune Reduced levoketoconazole exposure, reduced efficacy of levoketoconazole, increased risk of serious hepatotoxicity and drug-induced... Details Levoketoconazole Niacin Endur-Acin Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Nilutamide Nilandron Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Nitrofurantoin Furadantin Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Nizatidine Axid® Reduced levoketoconazole exposure Details Levoketoconazole Orlistat Alli Increased risk of serious hepatotoxicity and drug-induced liver injury Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.