Levoketoconazole

185 interactions 11 explained in plain English
Also sold as: Recorlev Recorlev®
About Levoketoconazole

Levoketoconazole is used to treat high levels of cortisol (a hormone produced by your adrenal glands) in patients with Cushing's syndrome (a condition in which the body produces too much cortisol) and who have failed surgery or cannot have surgery to treat this condition. Levoketoconazole is in a class of medications c… Read the full Levoketoconazole drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Contraindicated

Levoketoconazole Clindamycin ANTIROBE Explained Increased CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related adverse reaction Details Levoketoconazole Amitriptyline Elavil Explained An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Levoketoconazole Sertraline Explained An increased risk of QT interval prolongation and torsades pointes, an increased CYP3A4 substrate exposure and an increased risk o... Details Levoketoconazole Buprenorphine Belbuca Explained An increased risk of QT interval prolongation and torsades pointes, an increased CYP3A4 substrate exposure and an increased risk o... Details Levoketoconazole Relugolix Orgovyx Explained An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Levoketoconazole Colchicine Colcrys Explained Increased exposure of CYP3A4/P-gp substrate Details Levoketoconazole Simvastatin Flolipid Explained Increased CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related adverse reaction Details Levoketoconazole Abemaciclib Verzenio Explained Increased CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related adverse reaction Details Levoketoconazole Acalabrutinib Calquence Increased CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related adverse reaction Details Levoketoconazole Amisulpride Injection Barhemsys An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Levoketoconazole Arsenic Trioxide Trisenox An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Levoketoconazole Aripiprazole Injection Abilify An increased risk of QT interval prolongation and torsades pointes, an increased CYP3A4 substrate exposure and an increased risk o... Details Levoketoconazole Arsenic Trioxide Injection Trisenox An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Levoketoconazole Asenapine Transdermal Patch Secuado An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Levoketoconazole Avapritinib Ayvakit Increased CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related adverse reaction Details Levoketoconazole Azithromycin AzaSite An increased risk of QT interval prolongation, an increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Alfuzosin UroXatral An increased risk of QT interval prolongation and torsades pointes, an increased CYP3A4 substrate exposure and an increased risk o... Details Levoketoconazole Anagrelide Agrylin An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Levoketoconazole Avanafil Stendra Increased CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related adverse reaction Details Levoketoconazole Axitinib Inlyta Increased CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related adverse reaction Details Levoketoconazole Bedaquiline Sirturo An increased risk of QT interval prolongation and torsades pointes, an increased CYP3A4 substrate exposure and an increased risk o... Details Levoketoconazole Brigatinib Alunbrig Increased CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related adverse reaction Details Levoketoconazole Budesonide Entocort Increased CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related adverse reaction Details Levoketoconazole Budesonide Nasal Spray Rhinocort Increased CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related adverse reaction Details Levoketoconazole Budesonide Oral Inhalation Pulmicort Increased CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related adverse reaction Details Levoketoconazole Chloroquine Aralen® An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Levoketoconazole Clindamycin Injection ANTIROBE Increased CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related adverse reaction Details Levoketoconazole Clindamycin Topical C/T/S® Increased CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related adverse reaction Details Levoketoconazole Clindamycin Vaginal Cleocin Increased CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related adverse reaction Details Levoketoconazole Cyclosporine Injection Atopica Increased cycloSPORINE exposure, an increased risk of hepatotoxicity and a drug-induced liver injury Details Levoketoconazole Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure, an increased risk of hepatotoxicity and a drug-induced liver injury Details Levoketoconazole Dabigatran Pradaxa® Increased CYP3A4/P-gp substrate exposure Details Levoketoconazole Dabigatran Etexilate Increased CYP3A4/P-gp substrate exposure Details Levoketoconazole Dasatinib Phyrago An increased risk of QT interval prolongation, an increased CYP3A4 substrate exposure and an increased risk of CYP3A substrate-rel... Details Levoketoconazole Degarelix Injection Firmagon An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Levoketoconazole Deutetrabenazine Austedo An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Levoketoconazole Digoxin Cardoxin® Increased CYP3A4/P-gp substrate exposure Details Levoketoconazole Dihydroergotamine Injection DHE-45® Injection Increased CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related adverse reaction Details Levoketoconazole Dihydroergotamine Nasal Spray Migranal Increased CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related adverse reaction Details Levoketoconazole Disopyramide Norpace An increased risk of QT interval prolongation and torsades pointes, an increased CYP3A4 substrate exposure and an increased risk o... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.