Levomilnacipran

63 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Metoclopramide Nasal Spray Metoclopramide Injection Epoprostenol Diclofenac Topical (Actinic Keratosis) Palonosetron Injection
3 Contraindicated 59 Major 1 Moderate
All (63) Contraindicated (3) Major (59) Moderate (1)

Contraindicated

Levomilnacipran Linezolid Injection Zyvox An increased risk of serotonin syndrome Details Levomilnacipran Metoclopramide Injection Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Levomilnacipran Metoclopramide Nasal Spray Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details

Major

Levomilnacipran Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Levomilnacipran Amitriptyline Elavil Explained An increased risk of serotonin syndrome Details Levomilnacipran Sertraline Explained An increased risk of serotonin syndrome Details Levomilnacipran Buprenorphine Belbuca Explained An increased risk of serotonin syndrome Details Levomilnacipran Apixaban Eliquis Explained An increased risk of bleeding Details Levomilnacipran Aspirin Acuprin® An increased risk of bleeding Details Levomilnacipran Aspirin Rectal Aspirin An increased risk of bleeding Details Levomilnacipran Betrixaban Bevyxxa® An increased risk of bleeding Details Levomilnacipran Anagrelide Agrylin An increased risk of bleeding Details Levomilnacipran Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Levomilnacipran Butorphanol Injection Butorphic Increased risk of serotonin syndrome Details Levomilnacipran Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome Details Levomilnacipran Clopidogrel Plavix An increased risk of bleeding Details Levomilnacipran Dabigatran Pradaxa® An increased risk of bleeding Details Levomilnacipran Dabigatran Etexilate An increased risk of bleeding Details Levomilnacipran Dalteparin Injection Fragmin An increased risk of bleeding Details Levomilnacipran Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Levomilnacipran Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Levomilnacipran Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Levomilnacipran Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Levomilnacipran Dipyridamole Permole® An increased risk of bleeding Details Levomilnacipran Dolasetron Anzemet Increased risk of serotonin syndrome Details Levomilnacipran Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Levomilnacipran Edoxaban Savaysa Increased risk of bleeding Details Levomilnacipran Enoxaparin Lovenox An increased risk of bleeding Details Levomilnacipran Enoxaparin Injection Lovenox An increased risk of bleeding Details Levomilnacipran Epoprostenol Flolan An increased risk of bleeding Details Levomilnacipran Etodolac Lodine An increased risk of bleeding Details Levomilnacipran Fenoprofen Fenopron An increased risk of bleeding Details Levomilnacipran Fentanyl Transdermal Patch Duragesic® An increased risk of serotonin syndrome Details Levomilnacipran Flurbiprofen Ansaid An increased risk of bleeding Details Levomilnacipran Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details Levomilnacipran Fondaparinux Arixtra An increased risk of bleeding Details Levomilnacipran Fondaparinux Injection Arixtra An increased risk of bleeding Details Levomilnacipran Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Levomilnacipran Granisetron Injection Granisol Increased risk of serotonin syndrome Details Levomilnacipran Heparin An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.