Lomefloxacin

32 interactions 1 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Lixisenatide Injection Hydrocortisone Hydroxychloroquine Glipizide Dexamethasone Injection Miglitol

30 Major 2 Moderate

All (32) Major (30) Moderate (2)

Major

Lomefloxacin Acarbose Prandase® Explained Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Lomefloxacin Alogliptin Nesina Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Lomefloxacin Anagrelide Agrylin Increased anagrelide exposure Details Lomefloxacin Budesonide Entocort An increased risk of tendon rupture Details Lomefloxacin Budesonide Nasal Spray Rhinocort An increased risk of tendon rupture Details Lomefloxacin Budesonide Oral Inhalation Pulmicort An increased risk of tendon rupture Details Lomefloxacin Canagliflozin Invokana Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Lomefloxacin Dapagliflozin Farxiga Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Lomefloxacin Deflazacort Emflaza An increased risk of tendon rupture Details Lomefloxacin Dexamethasone Injection Decadron An increased risk of tendon rupture Details Lomefloxacin Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) An increased risk of tendon rupture Details Lomefloxacin Dulaglutide Injection Trulicity Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Lomefloxacin Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Lomefloxacin Ertugliflozin Steglatro Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Lomefloxacin Exenatide Injection Bydureon Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Lomefloxacin Fludrocortisone Acetate Florinef® An increased risk of tendon rupture Details Lomefloxacin Glimepiride Amaryl Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Lomefloxacin Glipizide Glucotrol Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Lomefloxacin Hydrocortisone Ala-Cort An increased risk of tendon rupture Details Lomefloxacin Hydrocortisone Injection A-Hydrocort® An increased risk of tendon rupture Details Lomefloxacin Hydroxychloroquine Plaquenil An increased risk of seizures Details Lomefloxacin Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Lomefloxacin Insulin Detemir (Rdna Origin) Injection Levemir Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Lomefloxacin Insulin Glulisine (Rdna Origin) Injection Apidra Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Lomefloxacin Linagliptin Tradjenta Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Lomefloxacin Liraglutide Injection Saxenda Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Lomefloxacin Lixisenatide Injection Adlyxin® Changes in blood glucose with an increased risk of hypoglycemia or hyperglycemia and delayed therapeutic effect of antibiotic Details Lomefloxacin Metformin Fortamet® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Lomefloxacin Miglitol Glyset® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Lomefloxacin Nateglinide Starlix® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details

Moderate

Lomefloxacin Didanosine Videx® Decreased lomefloxacin effectiveness Details Lomefloxacin Lanthanum Fosrenol® Reduced bioavailability of quinolone antibiotics Details

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