Loncastuximab Tesirine-Lpyl Injection

Name: Loncastuximab Tesirine-Lpyl Injection Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

15 interactions 19 cited references

Also sold as: Zynlonta Zynlonta®

About Loncastuximab Tesirine-Lpyl Injection

Loncastuximab tesirine-lpyl injection is used to treat a certain type of non-Hodgkin's lymphoma (NHL; a type of cancer that begins in a type of white blood cells that normally fights infection) that did not respond to or has returned after treatment with at least two other cancer treatments. Loncastuximab tesirine-lpyl… Read the full Loncastuximab Tesirine-Lpyl Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Typhoid Vaccine Mumps Virus Vaccine, Live Rubella Virus Vaccine, Live Smallpox Monkeypox Vaccine Measles Virus Vaccine, Live Varicella Virus Vaccine, Live

9 Contraindicated 6 Major

All (15) Contraindicated (9) Major (6)

Major

Loncastuximab Tesirine-Lpyl Injection Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Loncastuximab Tesirine-Lpyl Injection Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Loncastuximab Tesirine-Lpyl Injection Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Loncastuximab Tesirine-Lpyl Injection Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Loncastuximab Tesirine-Lpyl Injection Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details Loncastuximab Tesirine-Lpyl Injection Rotavirus Vaccine, Live An increased risk of infection by the live vaccine Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.