Loteprednol Etabonate

29 interactions 90 cited references

Also sold as: Alrex Eysuvis Inveltys Lotemax

Read the full Loteprednol Etabonate drug information page

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Desmopressin Mifepristone Aspirin Bemiparin Carbamazepine Cosyntropin

2 Contraindicated 18 Major 9 Moderate

All (29) Contraindicated (2) Major (18) Moderate (9)

Contraindicated

Loteprednol Etabonate Desmopressin DDAVP Increased risk of severe hyponatremia Details Loteprednol Etabonate Mifepristone Korlym An increased risk of autoimmune disorders and an increased risk of acute adrenal insufficiency, that may lead to exacerbation or d... Details

Major

Loteprednol Etabonate Aspirin Acuprin® An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Loteprednol Etabonate Bemiparin Increased risk of bleeding Details Loteprednol Etabonate Carbamazepine Carbatrol Reduced corticosteroids exposure and reduced efficacy of corticosteroids Details Loteprednol Etabonate Cosyntropin False elevations of plasma cortisol levels Details Loteprednol Etabonate Ethinyl Estradiol Increased corticosteroid exposure Details Loteprednol Etabonate Fosphenytoin Cerebyx Reduced corticosteroid exposure Details Loteprednol Etabonate Insulin Aspart, Recombinant Fiasp Reduced blood glucose lowering effect of insulin Details Loteprednol Etabonate Insulin Glargine, Recombinant Basaglar Reduced blood glucose lowering effect of insulin Details Loteprednol Etabonate Insulin Icodec-Abae Awiqli Reduced efficacy of insulin icodec-abae Details Loteprednol Etabonate Lutetium Lu 177 Dotatate Decreased lutetium Lu 177 dotatate efficacy Details Loteprednol Etabonate Macimorelin False-positive or false-negative adult growth hormone deficiency diagnosis Details Loteprednol Etabonate Nadroparin Increased risk of bleeding Details Loteprednol Etabonate Phenytoin Dilantin Reduced corticosteroid exposure Details Loteprednol Etabonate Rabies Vaccine Imovax An inadequate immunological response to the vaccine, an increased risk of altered immunocompetence and reduced immune response to... Details Loteprednol Etabonate Relacorilant Lifyorli Reduced relacorilant exposure and reduced efficacy of relacorilant, reduced glucocorticoids exposure and reduced efficacy of gluco... Details Loteprednol Etabonate Sargramostim Leukine Increased myeloproliferative effects of sargramostim Details Loteprednol Etabonate Somatrogon-Ghla Reduced serum cortisol exposure, an increased risk of central (secondary) hypoadrenalism and attenuated growth-promoting effects o... Details Loteprednol Etabonate Upadacitinib Rinvoq Increased risk of gastrointestinal perforations Details

Moderate

Loteprednol Etabonate Auranofin Ridaura Increased risk of auranofin-related adverse effects Details Loteprednol Etabonate Gallium Ga 68 Dotatate Increased risk of false negative imaging Details Loteprednol Etabonate Indapamide An increased risk of hypokalemia Details Loteprednol Etabonate Insulin Afrezza Reduced blood glucose lowering effect of insulin Details Loteprednol Etabonate Insulin Lispro, Recombinant Admelog May decrease blood glucose lowering effect of insulin lispro Details Loteprednol Etabonate Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details Loteprednol Etabonate Olodaterol Striverdi An increased risk of hypokalemia Details Loteprednol Etabonate Rotavirus Vaccine, Live An inadequate immunological response to the vaccine Details Loteprednol Etabonate Testosterone Androderm Increased risk of edema Details

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