Loxapine
33 interactions 3 explained in plain English
Also sold as:
Adasuve
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Metoclopramide Injection
Metoclopramide Nasal Spray
Acetaminophen And Codeine
Levodopa Oral Inhalation
Aripiprazole Injection
Glycopyrronium Topical
Major
Loxapine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Loxapine Amitriptyline Elavil Explained Potentiation of impaired cognitive function and motor skills and an increased risk of respiratory depression, hypotension, profoun... Details Loxapine Buprenorphine Belbuca Explained An increased risk of respiratory and CNS depression and an increased risk of paralytic ileus Details Loxapine Aripiprazole Injection Abilify Potentiation of impaired cognitive function and motor skills and an increased risk of respiratory depression, hypotension, profoun... Details Loxapine Asenapine Transdermal Patch Secuado Potentiation of impaired cognitive function and motor skills and an increased risk of respiratory depression, hypotension, profoun... Details Loxapine Cabergoline Dostinex® Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Details Loxapine Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Loxapine Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Loxapine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Loxapine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Loxapine Diazepam Nasal Spray Valtoco Potentiation of impaired cognitive function and motor skills and an increased risk of respiratory depression, hypotension, profoun... Details Loxapine Diazepam Rectal Diastat Potentiation of impaired cognitive function and motor skills and an increased risk of respiratory depression, hypotension, profoun... Details Loxapine Diphenhydramine Injection Banophen Potentiation of impaired cognitive function and motor skills and an increased risk of respiratory depression, hypotension, profoun... Details Loxapine Diphenhydramine Topical Afterbite with Antihistamine Potentiation of impaired cognitive function and motor skills and an increased risk of respiratory depression, hypotension, profoun... Details Loxapine Esketamine Nasal Spray Spravato Increased risk of sedation Details Loxapine Fentanyl Transdermal Patch Duragesic® Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Loxapine Glucagon Injection Baqsimi Increased risk of gastrointestinal side effects Details Loxapine Glucagon Injection / Solution Baqsimi Increased risk of gastrointestinal side effects Details Loxapine Glucagon Nasal Powder Baqsimi Increased risk of gastrointestinal side effects Details Loxapine Glycopyrronium Topical Cuvposa® An increased risk of anticholinergic side effects Details Loxapine Hydromorphone Injection Dilaudid Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Loxapine Hydromorphone Rectal available generically Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Loxapine Hydroxychloroquine Plaquenil An increased risk of seizures Details Loxapine Lacosamide Injection Motpoly An increased risk of CNS depression Details Loxapine Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Loxapine Lithium Carbonate Lithobid Weakness, dyskinesias, increased extrapyramidal symptoms, encephalopathy, and brain damage Details Loxapine Midazolam Nasal Spray Nayzilam Potentiation of impaired cognitive function and motor skills and an increased risk of respiratory depression, hypotension, profoun... Details Loxapine Midazolam Injection Nayzilam Potentiation of impaired cognitive function and motor skills and an increased risk of respiratory depression, hypotension, profoun... Details Loxapine Morphine Injection Astramorph® PF Increased risk of urinary retention, severe constipation, and paralytic ileus and an increased risk of profound sedation, respirat... Details Loxapine Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression; increased risk of paralytic ileus DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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