Lumiracoxib

91 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Ophthalmic Ketorolac Nasal Spray Ketorolac Injection Diclofenac Ophthalmic Pemetrexed Injection
4 Contraindicated 59 Major 28 Moderate
All (91) Contraindicated (4) Major (59) Moderate (28)

Major

Lumiracoxib Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Lumiracoxib Hydrocortisone Injection A-Hydrocort® Increased risk of gastrointestinal ulcer or bleeding Details Lumiracoxib Ibuprofen Addaprin An increased risk of gastrointestinal toxicity Details Lumiracoxib Iloprost Aurlumyn An increased risk of bleeding Details Lumiracoxib Ketoprofen Actron® Increased risk of bleeding Details Lumiracoxib Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Lumiracoxib Meclofenamate Meclodium® Increased risk of bleeding Details Lumiracoxib Mefenamic Acid Ponstel® Increased risk of bleeding Details Lumiracoxib Meloxicam Alloxate Increased risk of bleeding Details Lumiracoxib Meloxicam Injection Alloxate Increased risk of bleeding Details Lumiracoxib Melphalan Alkeran An increased risk of bleeding Details Lumiracoxib Melphalan Injection Alkeran An increased risk of bleeding Details Lumiracoxib Mesalamine Apriso Increased risk of bleeding Details Lumiracoxib Mesalamine Rectal Canasa Increased risk of bleeding Details Lumiracoxib Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Lumiracoxib Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Lumiracoxib Nabumetone Relafen Increased risk of bleeding Details Lumiracoxib Naproxen Aleve Increased risk of bleeding Details Lumiracoxib Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.