Lurbinectedin Injection

92 interactions 305 cited references
Also sold as: Zepzelca Zepzelca®
About Lurbinectedin Injection

Lurbinectedin injection is used to treat small cell lung cancer (SCLC) that has spread to other parts of the body and did not improve during or after treatment with platinum chemotherapy. Lurbinectedin injection is in a class of medications called alkylating agents. It works by slowing or stopping the growth of cancer… Read the full Lurbinectedin Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Lurbinectedin Injection Fluconazole Diflucan Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Fosamprenavir Lexiva Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Fosnetupitant Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Fosphenytoin Cerebyx Reduced lurbinectedin exposure and reduced efficacy of lurbinectedin Details Lurbinectedin Injection Idelalisib Zydelig Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Imatinib Gleevec Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Indinavir Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details Lurbinectedin Injection Isavuconazole Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Isavuconazonium Cresemba Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Itraconazole Sporanox Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Ivosidenib Tibsovo Reduced lurbinectedin exposure and reduced efficacy of lurbinectedin Details Lurbinectedin Injection Ketoconazole Extina Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Lefamulin Xenleta Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Lenacapavir Sunlenca Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Letermovir Prevymis Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Lonafarnib Zokinvy Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Lumacaftor Reduced lurbinectedin exposure and reduced efficacy of lurbinectedin Details Lurbinectedin Injection Mifepristone Korlym Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Mitotane Lysodren Reduced lurbinectedin exposure and reduced efficacy of lurbinectedin Details Lurbinectedin Injection Nefazodone Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Nelfinavir Viracept Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Netupitant Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Nilotinib Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Nirogacestat Ogsiveo Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Omaveloxolone Skyclarys Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Lurbinectedin Injection Paritaprevir Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Phenytoin Dilantin Reduced lurbinectedin exposure and reduced efficacy of lurbinectedin Details Lurbinectedin Injection Posaconazole Noxafil Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Relacorilant Lifyorli Increased CYP3A4 substrate exposure and an increased risk of CYP3A4-substrate-related adverse reactions Details Lurbinectedin Injection Ribociclib Kisqali Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Rifampin Rifadin Reduced lurbinectedin exposure and reduced efficacy of lurbinectedin Details Lurbinectedin Injection Rifapentine Priftin Reduced lurbinectedin exposure and reduced efficacy of lurbinectedin Details Lurbinectedin Injection Ritlecitinib Litfulo Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Ritonavir Norvir Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Rotavirus Vaccine, Live An increased risk of infection by the live vaccine Details Lurbinectedin Injection Saquinavir Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Schisandra Sphenanthera Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection St John's Wort Reduced lurbinectedin exposure and reduced efficacy of lurbinectedin Details Lurbinectedin Injection Tazemetostat Tazverik Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details

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