Lurbinectedin Injection

92 interactions 305 cited references

Also sold as: Zepzelca Zepzelca®

About Lurbinectedin Injection

Lurbinectedin injection is used to treat small cell lung cancer (SCLC) that has spread to other parts of the body and did not improve during or after treatment with platinum chemotherapy. Lurbinectedin injection is in a class of medications called alkylating agents. It works by slowing or stopping the growth of cancer… Read the full Lurbinectedin Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Yellow Fever Vaccine Rubella Virus Vaccine, Live Mumps Virus Vaccine, Live Measles Virus Vaccine, Live Ensitrelvir Dengue Tetravalent Vaccine, Live

10 Contraindicated 78 Major 4 Moderate

All (92) Contraindicated (10) Major (78) Moderate (4)

Contraindicated

Lurbinectedin Injection Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Lurbinectedin Injection Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Lurbinectedin Injection Ensitrelvir Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details Lurbinectedin Injection Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Lurbinectedin Injection Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Lurbinectedin Injection Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Lurbinectedin Injection Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Lurbinectedin Injection Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Lurbinectedin Injection Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Lurbinectedin Injection Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Lurbinectedin Injection Abametapir Increased exposure of CYP3A4 substrate Details Lurbinectedin Injection Adagrasib Krazati Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Lurbinectedin Injection Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Lurbinectedin Injection Amprenavir Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Apalutamide Erleada Reduced lurbinectedin exposure and reduced efficacy of lurbinectedin Details Lurbinectedin Injection Aprepitant Aponvie Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Atazanavir Reyataz Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Avacopan Tavneos Increased CYP3A4 substrate exposure Details Lurbinectedin Injection Berotralstat Orladeyo Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Boceprevir Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Carbamazepine Carbatrol Reduced lurbinectedin exposure and reduced efficacy of lurbinectedin Details Lurbinectedin Injection Ceritinib Zykadia Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Lurbinectedin Injection Ciprofloxacin Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Clarithromycin Biaxin Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Clofazimine Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Cobicistat Tybost Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Conivaptan Vaprisol Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Crizotinib Xalkori Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Darunavir Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Diltiazem Cardizem Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Dronedarone Multaq Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Duvelisib Copiktra Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Lurbinectedin Injection Encorafenib Braftovi Reduced lurbinectedin exposure and reduced efficacy of lurbinectedin Details Lurbinectedin Injection Enzalutamide Xtandi Reduced lurbinectedin exposure and reduced efficacy of lurbinectedin Details Lurbinectedin Injection Erythromycin Erythrocin Stearate Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Lurbinectedin Injection Fedratinib Inrebic Increased CYP3A4 substrate exposure Details Lurbinectedin Injection Fexinidazole An increased CYP3A4 substrate exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.