Lymecycline

18 interactions 1 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acitretin Methotrexate Penicillin V Potassium Methotrexate Injection Nafcillin Injection Penicillin G Benzathine Injection
1 Contraindicated 14 Major 3 Moderate
All (18) Contraindicated (1) Major (14) Moderate (3)

Contraindicated

Lymecycline Acitretin Soriatane® An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details

Major

Lymecycline Isotretinoin Absorica Explained An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Lymecycline Amoxicillin Amoxi Drop Decreased antibacterial effectiveness Details Lymecycline Ampicillin Amcill® Decreased antibacterial effectiveness Details Lymecycline Ampicillin Injection Omnipen-N® Decreased antibacterial effectiveness Details Lymecycline Bexarotene Targretin An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Lymecycline Bexarotene Topical Targretin An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Lymecycline Levonorgestrel After banger Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding and/or contrace... Details Lymecycline Levonorgestrel Intrauterine System Kyleena Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding and/or contrace... Details Lymecycline Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Lymecycline Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Lymecycline Nafcillin Injection Unipen® Injection Decreased antibacterial effectiveness Details Lymecycline Penicillin G Benzathine Injection Bicillin Decreased antibacterial effectiveness Details Lymecycline Penicillin G Procaine Injection Bactracillin G Decreased antibacterial effectiveness Details Lymecycline Penicillin V Potassium Beepen-VK® Decreased antibacterial effectiveness Details

Moderate

Lymecycline Glimepiride Amaryl Increased blood glucose lowering effect and increased risk of hypoglycemia Details Lymecycline Lanthanum Fosrenol® Reduced bioavailability of tetracyclines Details Lymecycline Lixisenatide Injection Adlyxin® Delayed therapeutic effect Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.