Magnesium Oxide

Name: Magnesium Oxide Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

51 interactions

Also sold as: Mag-Ox 400 Mag-Ox® Magmilax Maox® Phillips' Cramp-free Uro-Mag Uro-Mag®

About Magnesium Oxide

Magnesium is an element your body needs to function normally. Magnesium oxide may be used for different reasons. Some people use it as an antacid to relieve heartburn, sour stomach, or acid indigestion. Magnesium oxide also may be used as a laxative for short-term, rapid emptying of the bowel (before surgery, for examp… Read the full Magnesium Oxide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Mefenamic Acid Neratinib Octreotide Injection Hydroxychloroquine Erdafitinib Infigratinib

14 Major 30 Moderate 7 Minor

All (51) Major (14) Moderate (30) Minor (7)

Moderate

Magnesium Oxide Ofloxacin Ophthalmic Ocuflox Decreased oral ofloxacin effectiveness Details Magnesium Oxide Ofloxacin Otic Floxin® Otic Decreased oral ofloxacin effectiveness Details Magnesium Oxide Omadacycline Nuzyra Decreased effectiveness of omadacycline Details Magnesium Oxide Omadacycline Injection Nuzyra Decreased effectiveness of omadacycline Details

Minor

Magnesium Oxide Azithromycin AzaSite Reduced azithromycin exposure Details Magnesium Oxide Alendronate Binosto Decreased alendronate absorption Details Magnesium Oxide Bisacodyl Alophen Reformulated Jan 2008 Decreased effectiveness of bisacodyl Details Magnesium Oxide Bisacodyl Rectal Bisac-Evac Decreased effectiveness of bisacodyl Details Magnesium Oxide Didanosine Videx® An increased risk of adverse effects from the antacid Details Magnesium Oxide Etidronate Didronel® Decreased etidronate absorption Details Magnesium Oxide Glipizide Glucotrol Hypoglycemia (CNS depression, seizures) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.