Magnesium Oxide

51 interactions

Also sold as: Mag-Ox 400 Mag-Ox® Magmilax Maox® Phillips' Cramp-free Uro-Mag Uro-Mag®

About Magnesium Oxide

Magnesium is an element your body needs to function normally. Magnesium oxide may be used for different reasons. Some people use it as an antacid to relieve heartburn, sour stomach, or acid indigestion. Magnesium oxide also may be used as a laxative for short-term, rapid emptying of the bowel (before surgery, for examp… Read the full Magnesium Oxide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Mefenamic Acid Neratinib Octreotide Injection Hydroxychloroquine Erdafitinib Infigratinib

14 Major 30 Moderate 7 Minor

All (51) Major (14) Moderate (30) Minor (7)

Major

Magnesium Oxide Acalabrutinib Calquence Reduced acalabrutinib exposure Details Magnesium Oxide Cabotegravir Apretude Reduced cabotegravir plasma concentrations Details Magnesium Oxide Cefuroxime Ceftin® Decreased cefuroxime axetil exposure Details Magnesium Oxide Digoxin Cardoxin® Reduced digoxin exposure Details Magnesium Oxide Erdafitinib Balversa Altered serum phosphate levels Details Magnesium Oxide Ezetimibe Zetia Reduced ezetimibe exposure Details Magnesium Oxide Gefitinib Iressa Decreased exposure of gefitinib Details Magnesium Oxide Hydroxychloroquine Plaquenil Reduced hydroxychloroquine exposure Details Magnesium Oxide Infigratinib Truseltiq Decreased infigratinib plasma concentrations Details Magnesium Oxide Ketoconazole Topical Extina® Foam Reduced ketoconazole exposure and reduced efficacy of ketoconazole Details Magnesium Oxide Mefenamic Acid Ponstel® Increased exposure to mefenamic acid Details Magnesium Oxide Neratinib Nerlynx Decreased neratinib exposure Details Magnesium Oxide Octreotide Bynfezia Decreased octreotide bioavailability Details Magnesium Oxide Octreotide Injection Bynfezia Decreased octreotide bioavailability Details

Moderate

Magnesium Oxide Aspirin Acuprin® Decreased salicylate effectiveness Details Magnesium Oxide Aspirin Rectal Aspirin Decreased salicylate effectiveness Details Magnesium Oxide Bosutinib Bosulif Reduced bosutinib exposure Details Magnesium Oxide Calcitriol Rocaltrol Hypermagnesemia Details Magnesium Oxide Calcitriol Topical Vectical Hypermagnesemia Details Magnesium Oxide Captopril Capoten® Decreased captopril effectiveness Details Magnesium Oxide Cefdinir Omnicef® Decreased cefdinir efficacy Details Magnesium Oxide Cefpodoxime Banan® Decreased cefpodoxime effectiveness Details Magnesium Oxide Chloroquine Aralen® Decreased efficacy of chloroquine Details Magnesium Oxide Dasatinib Phyrago Reduced dasatinib exposure Details Magnesium Oxide Deflazacort Emflaza Decreased deflazacort effectiveness Details Magnesium Oxide Erlotinib Tarceva Reduced erlotinib exposure Details Magnesium Oxide Fexofenadine Allegra Decreased fexofenadine efficacy Details Magnesium Oxide Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details Magnesium Oxide Gemifloxacin Factive Decreased oral gemifloxacin effectiveness Details Magnesium Oxide Ibandronate Boniva Decreased ibandronate effectiveness Details Magnesium Oxide Ibandronate Injection Boniva Decreased ibandronate effectiveness Details Magnesium Oxide Levofloxacin Levaquin Decreased oral levofloxacin effectiveness Details Magnesium Oxide Levofloxacin Injection Levaquin Decreased oral levofloxacin effectiveness Details Magnesium Oxide Levothyroxine Ermeza Reduced efficacy of levothyroxine Details Magnesium Oxide Mesalamine Apriso Alteration of mesalamine bioavailability Details Magnesium Oxide Mesalamine Rectal Canasa Alteration of mesalamine bioavailability Details Magnesium Oxide Moxifloxacin Avelox Decreased oral moxifloxacin effectiveness Details Magnesium Oxide Moxifloxacin Injection Avelox Decreased oral moxifloxacin effectiveness Details Magnesium Oxide Moxifloxacin Ophthalmic Moxeza® Decreased oral moxifloxacin effectiveness Details Magnesium Oxide Ofloxacin Floxin® Decreased oral ofloxacin effectiveness Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.