Magnesium Oxide and Ezetimibe: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Magnesium Oxide
Ezetimibe
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Reduced ezetimibe exposure
Interaction Deep Dive
Coadministration of ezetimibe/rosuvastatin and antacids reduce ezetimibe exposure. In drug interaction studies, when aluminum and magnesium hydroxide combination antacid (20 ml single dose) coadministered with ezetimibe (10 mg), it decreased ezetimibe AUC by 4% and Cmax by 30%. Hence, in patients taking antacids, administer ezetimibe/rosuvastatin 2 hours before the antacid1.
Why it happens (mechanism)
Changes in gastric pH
Literature reports
1 report — tap to read
a) In drug interaction studies, when aluminum and magnesium hydroxide combination antacid (20 ml single dose) coadministered with ezetimibe (10 mg), it decreased ezetimibe AUC by 4% and Cmax by 30% 1.
Common questions
Can I take Magnesium Oxide and Ezetimibe together?
Reduced ezetimibe exposure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Magnesium Oxide and Ezetimibe interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Magnesium Oxide or Ezetimibe need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: ROSZET oral tablets, rosuvastatin ezetimibe oral tablets. Althera Pharmaceuticals LLC (per FDA), Wilmington, DE, 2024.
Keep reading about Magnesium Oxide
Keep reading about Ezetimibe
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
Check another combination
Our instant two-drug interaction checker is almost here.
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacist