Magnesium Sulfate

25 interactions

Read the full Magnesium Sulfate drug information page

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ofloxacin Ophthalmic Orlistat Hydroxychloroquine Moxifloxacin Injection Demeclocycline Gemifloxacin
24 Major 1 Moderate
All (25) Major (24) Moderate (1)

Major

Magnesium Sulfate Bisacodyl Alophen Reformulated Jan 2008 May increase the risk of mucosal ulceration or ischemic colitis Details Magnesium Sulfate Bisacodyl Rectal Bisac-Evac May increase the risk of mucosal ulceration or ischemic colitis Details Magnesium Sulfate Delafloxacin Baxdela May reduce absorption of fluoroquinolone antibiotics Details Magnesium Sulfate Delafloxacin Injection Baxdela May reduce absorption of fluoroquinolone antibiotics Details Magnesium Sulfate Demeclocycline Declomycin® May reduce absorption of tetracycline antibiotics Details Magnesium Sulfate Digoxin Cardoxin® Reduced absorption of digoxin Details Magnesium Sulfate Doxycycline Injection Acticlate May reduce absorption of tetracycline antibiotics Details Magnesium Sulfate Eravacycline Injection Xerava May reduce absorption of tetracycline antibiotics Details Magnesium Sulfate Gatifloxacin Ophthalmic Zymar® May reduce absorption of fluoroquinolone antibiotics Details Magnesium Sulfate Gemifloxacin Factive May reduce absorption of fluoroquinolone antibiotics Details Magnesium Sulfate Hydroxychloroquine Plaquenil Impaired antiepileptic activity Details Magnesium Sulfate Levofloxacin Levaquin May reduce absorption of fluoroquinolone antibiotics Details Magnesium Sulfate Levofloxacin Injection Levaquin May reduce absorption of fluoroquinolone antibiotics Details Magnesium Sulfate Minocycline Amzeeq May reduce absorption of tetracycline antibiotics Details Magnesium Sulfate Minocycline Topical Amzeeq May reduce absorption of tetracycline antibiotics Details Magnesium Sulfate Moxifloxacin Avelox May reduce absorption of fluoroquinolone antibiotics Details Magnesium Sulfate Moxifloxacin Injection Avelox May reduce absorption of fluoroquinolone antibiotics Details Magnesium Sulfate Moxifloxacin Ophthalmic Moxeza® May reduce absorption of fluoroquinolone antibiotics Details Magnesium Sulfate Ofloxacin Floxin® May reduce absorption of fluoroquinolone antibiotics Details Magnesium Sulfate Ofloxacin Ophthalmic Ocuflox May reduce absorption of fluoroquinolone antibiotics Details Magnesium Sulfate Ofloxacin Otic Floxin® Otic May reduce absorption of fluoroquinolone antibiotics Details Magnesium Sulfate Omadacycline Nuzyra May reduce absorption of tetracycline antibiotics Details Magnesium Sulfate Omadacycline Injection Nuzyra May reduce absorption of tetracycline antibiotics Details Magnesium Sulfate Orlistat Alli Reduced efficacy of anticonvulsant Details

Moderate

Magnesium Sulfate Labetalol Normodyne® Bradycardia and decreased cardiac output (shortness of breath, lightheadedness, or fainting spells) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.