Medroxyprogesterone and Tazemetostat: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Tazemetostat
Medroxyprogesterone
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives
Interaction Deep Dive
Concomitant use of tazemetostat and with CYP3A substrates, including hormonal contraceptives, may result in reduced hormonal contraceptive exposure and may also reduce efficacy of CYP3A substrates. Coadministration of tazemetostat with midazolam (a sensitive CYP3A substrate) decreased midazolam AUC by 40% and Cmax by 21%. Tazemetostat may render some hormonal contraceptives ineffective. Advise females of reproductive potential using tazemetostat to use effective non-hormonal contraception during treatment and for 6 months after the final dose1.
Why it happens (mechanism)
Induction of CYP3A-mediated contraceptive metabolism
Literature reports
1 report — tap to read
a) Concomitant use of tazemetostat 800 mg twice daily with oral midazolam (a sensitive CYP3A substrate) in patients decreased midazolam AUC (0 to 12) by 40% and Cmax by 21% 1.
Common questions
Can I take Medroxyprogesterone and Tazemetostat together?
Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Always confirm with your pharmacist or prescriber before making any change.
How serious is the Medroxyprogesterone and Tazemetostat interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Medroxyprogesterone or Tazemetostat need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: TAZVERIK(R) oral tablets, tazemetostat oral tablets. Epizyme Inc (per FDA), Cambridge, MA, 2024. DailyMed
Keep reading about Tazemetostat
Keep reading about Medroxyprogesterone
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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