Tazemetostat

110 interactions 12 explained in plain English

Also sold as: Tazverik

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Axitinib Budesonide Irinotecan Injection Dasatinib Nintedanib Olaparib

109 Major 1 Moderate

All (110) Major (109) Moderate (1)

Major

Tazemetostat Acetaminophen And Codeine Capital® & Codeine Explained Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Abametapir Explained Increased exposure of CYP3A4 substrate Details Tazemetostat Clindamycin ANTIROBE Explained Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Omeprazole Gastrobim Explained Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Sertraline Explained Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Buprenorphine Belbuca Explained Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Colchicine Colcrys Explained Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Simvastatin Flolipid Explained Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Abemaciclib Verzenio Explained Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Acalabrutinib Calquence Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Apixaban Eliquis Explained Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Aripiprazole Injection Abilify Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Asciminib Scemblix Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Atogepant Qulipta Reduced atogepant exposure Details Tazemetostat Avapritinib Ayvakit Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Avatrombopag Doptelet Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Belumosudil Rezurock Explained Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Atorvastatin Atorvaliq Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Cariprazine Vraylar Explained Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Abiraterone Abirtega Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Alfuzosin UroXatral Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Amlodipine Amvaz® Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Avanafil Stendra Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Axitinib Inlyta Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Bedaquiline Sirturo Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Bosutinib Bosulif Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Brexpiprazole Rexulti Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Brigatinib Alunbrig Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Budesonide Entocort Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Budesonide Nasal Spray Rhinocort Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Budesonide Oral Inhalation Pulmicort Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Cabozantinib Cabometyx Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Cabozantinib (Thyroid Cancer) Cabometyx Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Capmatinib Tabrecta Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Clindamycin Injection ANTIROBE Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Clindamycin Topical C/T/S® Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Clindamycin Vaginal Cleocin Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Cobimetinib Cotellic Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Darolutamide Nubeqa Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tazemetostat Dasatinib Phyrago Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.