Mefenamic Acid

309 interactions 276 cited references
Also sold as: Ponstel®
About Mefenamic Acid

Mefenamic acid is used to relieve mild to moderate pain, including menstrual pain (pain that happens before or during a menstrual period). Mefenamic acid is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation. Read the full Mefenamic Acid drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Injection Ketorolac Ophthalmic Ketorolac Nasal Spray Ketorolac Pemetrexed Injection Hydrochlorothiazide
4 Contraindicated 246 Major 59 Moderate
All (309) Contraindicated (4) Major (246) Moderate (59)

Contraindicated

Mefenamic Acid Ketorolac Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Mefenamic Acid Ketorolac Injection Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Mefenamic Acid Ketorolac Nasal Spray Sprix Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Mefenamic Acid Ketorolac Ophthalmic Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details

Major

Mefenamic Acid Amitriptyline Elavil An increased risk of bleeding Details Mefenamic Acid Sertraline An increased risk of bleeding Details Mefenamic Acid Apixaban Eliquis An increased risk of bleeding Details Mefenamic Acid Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Mefenamic Acid Aspirin Rectal Aspirin An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Mefenamic Acid Azathioprine Azasan An increased risk of hepatotoxicity Details Mefenamic Acid Betrixaban Bevyxxa® An increased risk of bleeding Details Mefenamic Acid Anagrelide Agrylin An increased risk of bleeding Details Mefenamic Acid Bromfenac Ophthalmic Bromday® Increased risk of bleeding Details Mefenamic Acid Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Mefenamic Acid Budesonide Nasal Spray Rhinocort Increased risk of gastrointestinal ulcer or bleeding Details Mefenamic Acid Budesonide Oral Inhalation Pulmicort Increased risk of gastrointestinal ulcer or bleeding Details Mefenamic Acid Clopidogrel Plavix An increased risk of bleeding Details Mefenamic Acid Cyclosporine Injection Atopica An increased risk of cycloSPORINE nephrotoxicity Details Mefenamic Acid Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE nephrotoxicity Details Mefenamic Acid Dabigatran Pradaxa® An increased risk of bleeding Details Mefenamic Acid Dabigatran Etexilate An increased risk of bleeding Details Mefenamic Acid Dalteparin Injection Fragmin An increased risk of bleeding Details Mefenamic Acid Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Mefenamic Acid Dexamethasone Injection Decadron Increased risk of gastrointestinal ulcer or bleeding Details Mefenamic Acid Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal ulcer or bleeding Details Mefenamic Acid Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of bleeding Details Mefenamic Acid Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of bleeding Details Mefenamic Acid Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of bleeding Details Mefenamic Acid Diclofenac Transdermal Patch Flector Increased risk of bleeding Details Mefenamic Acid Digoxin Cardoxin® Increased digoxin exposure and prolonged half-life of digoxin Details Mefenamic Acid Dipyridamole Permole® An increased risk of bleeding Details Mefenamic Acid Edoxaban Savaysa An increased risk of bleeding Details Mefenamic Acid Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Mefenamic Acid Enoxaparin Lovenox An increased risk of bleeding Details Mefenamic Acid Enoxaparin Injection Lovenox An increased risk of bleeding Details Mefenamic Acid Epoprostenol Flolan An increased risk of bleeding Details Mefenamic Acid Etodolac Lodine Increased risk of bleeding Details Mefenamic Acid Fenoprofen Fenopron Increased risk of bleeding Details Mefenamic Acid Flurbiprofen Ansaid Increased risk of bleeding Details Mefenamic Acid Flurbiprofen Ophthalmic Ocufen Increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.