Mefenamic Acid

309 interactions 276 cited references
Also sold as: Ponstel®
About Mefenamic Acid

Mefenamic acid is used to relieve mild to moderate pain, including menstrual pain (pain that happens before or during a menstrual period). Mefenamic acid is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation. Read the full Mefenamic Acid drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Moderate

Mefenamic Acid Lisinopril Prinivil Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Mefenamic Acid Atenolol Tenormin Reduced antihypertensive effect Details Mefenamic Acid Acebutolol Sectral® Reduced antihypertensive effect Details Mefenamic Acid Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Mefenamic Acid Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Mefenamic Acid Betaxolol Betoptic S Reduced antihypertensive effect Details Mefenamic Acid Betaxolol Ophthalmic Betoptic® Reduced antihypertensive effect Details Mefenamic Acid Bisoprolol Zebeta® Reduced antihypertensive effect Details Mefenamic Acid Captopril Capoten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Mefenamic Acid Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Mefenamic Acid Enalapril Epaned Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Mefenamic Acid Eprosartan Teveten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Mefenamic Acid Esmolol Brevibloc Reduced antihypertensive effect Details Mefenamic Acid Fosinopril Monopril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Mefenamic Acid Irbesartan Avapro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Mefenamic Acid Labetalol Normodyne® Reduced antihypertensive effect Details Mefenamic Acid Levobunolol Ophthalmic AKBeta® Reduced antihypertensive effect Details Mefenamic Acid Levofloxacin Levaquin An increased risk of seizures Details Mefenamic Acid Levofloxacin Injection Levaquin An increased risk of seizures Details Mefenamic Acid Losartan Arbli Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Mefenamic Acid Anisindione An increased risk of bleeding Details Mefenamic Acid Azilsartan Medoxomil Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Mefenamic Acid Candesartan Atacand Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Mefenamic Acid Carteolol Reduced antihypertensive effect Details Mefenamic Acid Carvedilol Coreg Reduced antihypertensive effect Details Mefenamic Acid Celiprolol Reduced antihypertensive effect Details Mefenamic Acid Ciprofloxacin An increased risk of convulsions Details Mefenamic Acid Desmopressin DDAVP Increased risk of water intoxication with hyponatremia Details Mefenamic Acid Dicumarol An increased risk of bleeding Details Mefenamic Acid Enalaprilat Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Mefenamic Acid Ginkgo An increased risk of bleeding Details Mefenamic Acid Levobunolol Betagan Reduced antihypertensive effect Details Mefenamic Acid L-Methylfolate Decreased l-methylfolate efficacy Details Mefenamic Acid Ma Huang Increased risk of developing gastric mucosal lesions Details Mefenamic Acid Metipranolol Reduced antihypertensive effect Details Mefenamic Acid Metoprolol Kapspargo Reduced antihypertensive effect Details Mefenamic Acid Moexipril Univasc® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Mefenamic Acid Nadolol Corgard Reduced antihypertensive effect Details Mefenamic Acid Nebivolol Bystolic Reduced antihypertensive effect Details Mefenamic Acid Norfloxacin An increased risk of seizures Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.