Mefenamic Acid

309 interactions 276 cited references
Also sold as: Ponstel®
About Mefenamic Acid

Mefenamic acid is used to relieve mild to moderate pain, including menstrual pain (pain that happens before or during a menstrual period). Mefenamic acid is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation. Read the full Mefenamic Acid drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Injection Ketorolac Ophthalmic Ketorolac Nasal Spray Ketorolac Pemetrexed Injection Hydrochlorothiazide
4 Contraindicated 246 Major 59 Moderate
All (309) Contraindicated (4) Major (246) Moderate (59)

Moderate

Mefenamic Acid Ofloxacin Floxin® An increased risk of seizures Details Mefenamic Acid Olmesartan Benicar Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Mefenamic Acid Oxprenolol Reduced antihypertensive effect Details Mefenamic Acid Penbutolol Levatol® Reduced antihypertensive effect Details Mefenamic Acid Perindopril Aceon Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Mefenamic Acid Pindolol Visken® Reduced antihypertensive effect Details Mefenamic Acid Pralatrexate Increased pralatrexate exposure Details Mefenamic Acid Propranolol Hemangeol Reduced antihypertensive effect Details Mefenamic Acid Quinapril Accupril Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Mefenamic Acid Ramipril Altace Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Mefenamic Acid Sotalol Betapace Reduced antihypertensive effect Details Mefenamic Acid Sparsentan Filspari An increased risk of worsening of renal function Details Mefenamic Acid Spirapril Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Mefenamic Acid Telmisartan Micardis Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Mefenamic Acid Timolol Betimol Reduced antihypertensive effect Details Mefenamic Acid Trandolapril Mavik® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Mefenamic Acid Valsartan Diovan Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Mefenamic Acid Ofloxacin Ophthalmic Ocuflox An increased risk of seizures Details Mefenamic Acid Ofloxacin Otic Floxin® Otic An increased risk of seizures Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.