Mefloquine

256 interactions 454 cited references

Also sold as: Lariam®

About Mefloquine

Mefloquine is used to treat malaria (a serious infection that is spread by mosquitoes in certain parts of the world and can cause death) and to prevent malaria in travelers who visit areas where malaria is common. Mefloquine is in a class of medications called antimalarials. It works by killing the organisms that cause… Read the full Mefloquine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levoketoconazole Saquinavir Piperaquine Pimozide Mesoridazine Levomethadyl

15 Contraindicated 236 Major 5 Moderate

All (256) Contraindicated (15) Major (236) Moderate (5)

Contraindicated

Mefloquine Isradipine DynaCirc® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Mefloquine Aurothioglucose An increased risk of blood dyscrasias Details Mefloquine Bepridil An increased risk of QT interval prolongation Details Mefloquine Cisapride Propulsid® Increased risk of QT interval prolongation Details Mefloquine Dronedarone Multaq Increased risk of QT interval prolongation Details Mefloquine Levoketoconazole Recorlev An increased risk of QT interval prolongation, an increased risk of serious hepatotoxicity and drug-induced liver injury Details Mefloquine Levomethadyl An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Mefloquine Mesoridazine An increased risk of QT interval prolongation Details Mefloquine Pimozide An increased risk of QT interval prolongation Details Mefloquine Piperaquine An increased risk of QT interval prolongation Details Mefloquine Saquinavir An increased risk of QT interval prolongation Details Mefloquine Sparfloxacin An increased risk of QT interval prolongation Details Mefloquine Terfenadine An increased risk of QT interval prolongation Details Mefloquine Thioridazine An increased risk of QT interval prolongation Details Mefloquine Ziprasidone Geodon An increased risk of QT interval prolongation Details

Major

Mefloquine Amitriptyline Elavil An increased risk of QT interval prolongation Details Mefloquine Sertraline An increased risk of QT interval prolongation Details Mefloquine Buprenorphine Belbuca An increased risk of QT interval prolongation Details Mefloquine Relugolix Orgovyx Increased risk of QT interval prolongation Details Mefloquine Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Mefloquine Arsenic Trioxide Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Mefloquine Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Mefloquine Arsenic Trioxide Injection Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Mefloquine Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Mefloquine Azathioprine Azasan An increased risk of hepatotoxicity Details Mefloquine Azithromycin AzaSite An increased risk of QT interval prolongation Details Mefloquine Alfuzosin UroXatral An increased risk of QT interval prolongation Details Mefloquine Anagrelide Agrylin Increased risk of QT interval prolongation Details Mefloquine Bedaquiline Sirturo Increased risk of QT interval prolongation Details Mefloquine Chloroquine Aralen® An increased risk of convulsions, electrocardiogram abnormalities, cardiac arrest Details Mefloquine Dasatinib Phyrago An increased risk of QT interval prolongation Details Mefloquine Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Mefloquine Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Mefloquine Disopyramide Norpace An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Mefloquine Dofetilide Tikosyn An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Mefloquine Dolasetron Anzemet An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Mefloquine Dolasetron Injection Anzemet An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Mefloquine Encorafenib Braftovi Increased risk of QT interval prolongation Details Mefloquine Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Mefloquine Flecainide Tambocor® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.