Melphalan Flufenamide Injection

Name: Melphalan Flufenamide Injection Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

15 interactions 18 cited references

Also sold as: Pepaxto®

About Melphalan Flufenamide Injection

Melphalan flufenamide injection is used along with dexamethasone to treat multiple myeloma (a type of cancer of the bone marrow) in adults whose disease has returned or has not improved after receiving at least four other chemotherapy medications. Melphalan flufenamide is in a class of medications called alkylating age… Read the full Melphalan Flufenamide Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Typhoid Vaccine Mumps Virus Vaccine, Live Rubella Virus Vaccine, Live Smallpox Monkeypox Vaccine Measles Virus Vaccine, Live Varicella Virus Vaccine, Live

9 Contraindicated 6 Major

All (15) Contraindicated (9) Major (6)

Major

Melphalan Flufenamide Injection Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Melphalan Flufenamide Injection Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Melphalan Flufenamide Injection Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Melphalan Flufenamide Injection Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Melphalan Flufenamide Injection Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details Melphalan Flufenamide Injection Rotavirus Vaccine, Live An increased risk of infection by the live vaccine Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.