Melphalan and Dengue Tetravalent Vaccine, Live: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Melphalan
Dengue Tetravalent Vaccine, Live
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of infection by the live vaccine
Interaction Deep Dive
Do not administer dengue virus vaccine to individuals with severe immunodeficiency or immunosuppression due to disease or therapy2. Patients with leukemia, lymphoma, or other malignancies whose disease is in remission, who have restored immunocompetence, and whose chemotherapy has been discontinued for at least 3 months can receive a live vaccine 1.
Why it happens (mechanism)
Decreased immune response allows live vaccine to produce infection
Common questions
Can I take Melphalan and Dengue Tetravalent Vaccine, Live together?
An increased risk of infection by the live vaccine Always confirm with your pharmacist or prescriber before making any change.
How serious is the Melphalan and Dengue Tetravalent Vaccine, Live interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "established". Well documented — supported by controlled studies or strong clinical data.
Questions for your pharmacist
- Does my dose of Melphalan or Dengue Tetravalent Vaccine, Live need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Centers for Disease Control and Prevention (CDC): Vaccines & Immunizations: altered immunocompetence. Centers for Disease Control and Prevention (CDC). Atlanta, GA. 2024.
- Product Information: DENGVAXIA(R) subcutaneous injection suspension, dengue tetravalent vaccine, live subcutaneous injection suspension. Sanofi Pasteur Inc (per manufacturer), Swiftwater, PA, 2019. DailyMed
Keep reading about Melphalan
Keep reading about Dengue Tetravalent Vaccine, Live
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
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