Melphalan

156 interactions 460 cited references

Also sold as: Alkeran Alkeran® Tablets Evomela Hepzato Ivra

About Melphalan

Melphalan is used to treat multiple myeloma (a type of cancer of the bone marrow). Melphalan is also used to treat a certain type of ovarian cancer (cancer that begins in the female reproductive organs where eggs are formed). Melphalan is in a class of medications called alkylating agents. It works by stopping or slowi… Read the full Melphalan drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Measles Virus Vaccine, Live Dengue Tetravalent Vaccine, Live Bacillus Of Calmette And Guerin Vaccine, Live Rubella Virus Vaccine, Live Smallpox Monkeypox Vaccine Mumps Virus Vaccine, Live

9 Contraindicated 145 Major 2 Moderate

All (156) Contraindicated (9) Major (145) Moderate (2)

Contraindicated

Melphalan Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Melphalan Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Melphalan Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Melphalan Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Melphalan Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Melphalan Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Melphalan Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Melphalan Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Melphalan Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Melphalan Lisinopril Prinivil An increased risk of severe hypotension Details Melphalan Apixaban Eliquis An increased risk of bleeding Details Melphalan Aspirin Acuprin® An increased risk of bleeding Details Melphalan Aspirin Rectal Aspirin An increased risk of bleeding Details Melphalan Benazepril Lotensin An increased risk of severe hypotension Details Melphalan Alfuzosin UroXatral An increased risk of severe hypotension Details Melphalan Amlodipine Amvaz® An increased risk of severe hypotension Details Melphalan Anagrelide Agrylin An increased risk of bleeding Details Melphalan Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Melphalan Captopril Capoten® An increased risk of severe hypotension Details Melphalan Carmustine BiCNU An increased risk of lung toxicity Details Melphalan Carmustine Implant Gliadel An increased risk of lung toxicity Details Melphalan Cisplatin Injection Platinol-AQ® Altered melphalan clearance Details Melphalan Clopidogrel Plavix An increased risk of bleeding Details Melphalan Cyclosporine Injection Atopica An increased risk of severe renal failure Details Melphalan Cyclosporine Ophthalmic Cequa An increased risk of severe renal failure Details Melphalan Dabigatran Pradaxa® An increased risk of bleeding Details Melphalan Dabigatran Etexilate An increased risk of bleeding Details Melphalan Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Melphalan Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Melphalan Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Melphalan Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Melphalan Dipyridamole Permole® An increased risk of bleeding Details Melphalan Doxazosin Cardura An increased risk of severe hypotension Details Melphalan Edoxaban Savaysa An increased risk of bleeding Details Melphalan Enalapril Epaned An increased risk of severe hypotension Details Melphalan Etodolac Lodine An increased risk of bleeding Details Melphalan Felodipine Plendil® An increased risk of severe hypotension Details Melphalan Fenoprofen Fenopron An increased risk of bleeding Details Melphalan Flurbiprofen Ansaid An increased risk of bleeding Details Melphalan Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.