Metaxalone

30 interactions 4 explained in plain English

Also sold as: Skelaxin

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Nalbuphine Injection Palonosetron Injection Levodopa Oral Inhalation Dolasetron Diazepam Rectal

29 Major 1 Moderate

All (30) Major (29) Moderate (1)

Major

Metaxalone Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome, an increased risk of respiratory depression and an increased risk of CNS depression Details Metaxalone Amitriptyline Elavil Explained Increased risk of serotonin syndrome Details Metaxalone Sertraline Explained Increased risk of serotonin syndrome Details Metaxalone Buprenorphine Belbuca Explained Increased risk of serotonin syndrome, an increased risk of respiratory depression and an increased risk of CNS depression Details Metaxalone Butorphanol Injection Butorphic Increased risk of serotonin syndrome, an increased risk of respiratory depression and an increased risk of CNS depression Details Metaxalone Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome, an increased risk of respiratory depression and an increased risk of CNS depression Details Metaxalone Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Metaxalone Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Metaxalone Diazepam Nasal Spray Valtoco Additive respiratory depression Details Metaxalone Diazepam Rectal Diastat Additive respiratory depression Details Metaxalone Dolasetron Anzemet Increased risk of serotonin syndrome Details Metaxalone Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Metaxalone Esketamine Nasal Spray Spravato Increased risk of sedation Details Metaxalone Fentanyl Transdermal Patch Duragesic® Increased risk of serotonin syndrome, an increased risk of respiratory depression and an increased risk of CNS depression Details Metaxalone Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Metaxalone Granisetron Injection Granisol Increased risk of serotonin syndrome Details Metaxalone Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome, an increased risk of respiratory depression and an increased risk of CNS depression Details Metaxalone Hydromorphone Rectal available generically Increased risk of serotonin syndrome, an increased risk of respiratory depression and an increased risk of CNS depression Details Metaxalone Lacosamide Injection Motpoly An increased risk of CNS depression Details Metaxalone Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Metaxalone Linezolid Injection Zyvox Increased risk of serotonin syndrome Details Metaxalone Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Metaxalone Metoclopramide Injection Gimoti Increased risk of CNS depression Details Metaxalone Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Metaxalone Midazolam Nasal Spray Nayzilam Additive respiratory depression Details Metaxalone Midazolam Injection Nayzilam Additive respiratory depression Details Metaxalone Morphine Injection Astramorph® PF Increased risk of serotonin syndrome, an increased risk of respiratory depression and an increased risk of CNS depression Details Metaxalone Nalbuphine Injection Nubain® Increased risk of serotonin syndrome, an increased risk of respiratory depression and an increased risk of CNS depression Details Metaxalone Palonosetron Injection Aloxi® Increased risk of serotonin syndrome Details

Moderate

Metaxalone Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.