Methadone

Name: Methadone Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

129 interactions 10 explained in plain English

Also sold as: Diskets Dolophine Methadose

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Nalbuphine Injection Diazepam Rectal Flecainide Palonosetron Injection Midazolam Injection

1 Contraindicated 125 Major 3 Moderate

All (129) Contraindicated (1) Major (125) Moderate (3)

Major

Methadone Ofloxacin Ophthalmic Ocuflox Increased risk of QT interval prolongation Details Methadone Ofloxacin Otic Floxin® Otic Increased risk of QT interval prolongation Details Methadone Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Methadone Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details Methadone Oxandrolone Oxandrin Increased methadone exposure and an increased risk of opioid adverse effects Details Methadone Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

Moderate

Methadone Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Methadone Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Methadone Peginterferon Alfa-2A Injection Pegasys Increased methadone concentrations Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.