Methadone

Contraindicated

Methadone Ketoconazole Topical Extina® Foam Increased methadone exposure and an increased risk of QT interval prolongation Details

Major

Methadone Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Methadone Abacavir Ziagen Explained Increased methadone plasma clearance and reduced methadone exposure Details Methadone Abametapir Explained Increased exposure of CYP3A4 substrate Details Methadone Omeprazole Gastrobim Explained Increased methadone exposure and an increased risk of opioid adverse effects Details Methadone Amitriptyline Elavil Explained Increased risk of serotonin syndrome, increased risk of paralytic ileus and an increased risk of QT prolongation Details Methadone Sertraline Explained Increased QT interval prolongation, increased risk of serotonin syndrome, increased methadone exposure and an increased risk of op... Details Methadone Buprenorphine Belbuca Explained Reduced analgesic effect or precipitation of withdrawal symptoms, an increased risk of serotonin syndrome, an increased risk of re... Details Methadone Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Methadone Trospium / Xanomeline Cobenfy Explained Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Methadone Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Methadone Arsenic Trioxide Trisenox Increased risk of QT interval prolongation Details Methadone Aripiprazole Injection Abilify Increased risk of respiratory and CNS depression and an increased risk of QT prolongation Details Methadone Arsenic Trioxide Injection Trisenox Increased risk of QT interval prolongation Details Methadone Asenapine Transdermal Patch Secuado Increased risk of respiratory and CNS depression and an increased risk of QT prolongation Details Methadone Azithromycin AzaSite Increased risk of QT interval prolongation Details Methadone Cariprazine Vraylar Explained Increased risk of respiratory and CNS depression Details Methadone Abiraterone Abirtega Increased methadone exposure and an increased risk of opioid adverse effects Details Methadone Aclidinium Oral Inhalation Tudorza Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Methadone Alfuzosin UroXatral Increased risk of QT interval prolongation Details Methadone Anagrelide Agrylin Increased risk of QT interval prolongation Details Methadone Atropine Ophthalmic Atropine Care 1% Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Methadone Bedaquiline Sirturo Increased risk of QT interval prolongation Details Methadone Brexpiprazole Rexulti Increased brexpiprazole exposure Details Methadone Butorphanol Injection Butorphic Reduced analgesic effect or precipitation of withdrawal symptoms and an increased risk of serotonin syndrome Details Methadone Butorphanol Nasal Spray Stadol® NS Reduced analgesic effect or precipitation of withdrawal symptoms and an increased risk of serotonin syndrome Details Methadone Capecitabine Xeloda Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Methadone Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Methadone Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Methadone Chloroquine Aralen® Increased risk of QT interval prolongation Details Methadone Clopidogrel Plavix Increased methadone exposure, an increased risk of opioid adverse effects and reduced efficacy of clopidogrel Details Methadone Cyclopentolate Ophthalmic Akpentolate® Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Methadone Cyclosporine Injection Atopica Increased methadone exposure and an increased risk of opioid adverse effects Details Methadone Cyclosporine Ophthalmic Cequa Increased methadone exposure and an increased risk of opioid adverse effects Details Methadone Dasatinib Phyrago Increased risk of QT interval prolongation Details Methadone Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Methadone Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Methadone Dexamethasone Injection Decadron Reduced methadone exposure and an increased risk of opioid withdrawal symptoms Details Methadone Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced methadone exposure and an increased risk of opioid withdrawal symptoms Details Methadone Diazepam Nasal Spray Valtoco Increased risk of respiratory and CNS depression Details